Evaluation in Healthy Subjects of a Transcutaneous Carbon Dioxide Monitoring Wristband during Hypo and Hypercapnia Conditions*
Evaluation in Healthy Subjects of a Transcutaneous Carbon Dioxide Monitoring Wristband during Hypo and Hypercapnia Conditions*
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在低碳酸血症和高碳酸血症条件下对健康受试者进行经皮二氧化碳监测腕带的评估*
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发表时间：
2020
期刊：
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通讯作者：
S. Vergès
中科院分区：
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作者：
P. Grangeat;S. Gharbi;A. Koenig;Maria;M. Accensi;H. Grateau;Abdallah Ghaith;S. Chacaroun;S. Doutreleau;S. Vergès
用于医疗监测的可穿戴设备的开发是主要关注的，特别是对于家庭护理应用。但是，开发一个评估框架来通过遵循非侵入性协议来测试和优化这样的设备是具有挑战性的。由于二氧化碳测定确实存在成熟的参考设备，我们提出了一个协议来评估和比较我们开发的经皮二氧化碳监测腕带的性能。我们在这里提出了这个协议，信号处理管道和数据分析的基础上，信号对齐和相互关联的研究，以及第一批结果的队列中的13名健康受试者。该测试可证明器械响应时间和环境空气中二氧化碳含量的影响。临床相关性-此处描述的方案可在模拟受试者休息时低碳酸血症和高碳酸血症变化的临床条件下测试和优化新器械，如在家中监测慢性呼吸道患者的健康状况，并将性能与参考器械进行比较。在13名健康受试者中的5名中观察到大于0.8的强相关性，并提出了影响相关性的因素。
The development of wearable devices for healthcare monitoring is of primary interest, in particular for homecare applications. But it is challenging to develop an evaluation framework to test and optimize such a device by following a non-invasive protocol. As well established reference devices do exist for capnometry, we propose a protocol to evaluate and compare the performance of the transcutaneous carbon dioxide monitoring wristband that we develop. We present here this protocol, the signal processing pipeline and the data analysis based on signal alignment and intercorrelation study, and the first results on a cohort of 13 healthy subjects. This test allows demonstrating the influence of the device response time and of the carbon dioxide content in the ambient air.Clinical Relevance—The protocol described here allows to test and optimize the new device in clinical conditions simulating hypo and hypercapnia variations on a subject at rest, as it would be the case at home to monitor the health status of chronic respiratory patients, and to compare the performances with reference devices. A strong intercorrelation greater than 0.8 has been observed in 5 healthy subjects out of 13 and factors influencing the intercorrelation are suggested.