Prions are affected by evolution at two levels.
Prions are affected by evolution at two levels.
复制标题
DOI：
10.1007/s00018-015-2109-6
复制
发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Kelly AC
中科院分区：
文献类型：
--
作者：
Wickner RB;Kelly AC
朊病毒，传染性蛋白，可以传播疾病或成为遗传特征的基础（或两者兼而有之），大多数基于朊病毒蛋白的淀粉样形式。单个蛋白序列可以成为许多朊病毒菌株/变体的基础，它们根据不同的淀粉样蛋白构象具有不同的生物学特性，每一种都相当稳定地繁殖。朊病毒的独特之处在于，它的进化和选择在编码蛋白质的染色体基因水平和朊病毒自身选择朊病毒变体的水平上都起作用。在这里，我们总结了已知的朊病毒蛋白的进化，基因和朊病毒本身。我们将已知的一种功能性猪脚孢子虫朊病毒[ht -s]与已知的疾病朊病毒，酵母朊病毒[PSI+]和[URE3]以及哺乳动物传染性海绵状脑病进行了比较。
Prions, infectious proteins, can transmit diseases or be the basis of heritable traits (or both), most based on amyloid forms of the prion protein. A single protein sequence can be the basis for many prion strains/variants, with different biological properties based on different amyloid conformations, each rather stably propagating. Prions are unique in that evolution and selection work at both the level of the chromosomal gene encoding the protein, and on the prion itself selecting prion variants. Here we summarize what is known about the evolution of prion proteins, both the genes and the prions themselves. We contrast the one known functional prion, [Het-s] of Podospora anserina, with the known disease prions, the yeast prions [PSI+] and [URE3] and the transmissible spongiform encephalopathies of mammals.