A multidisciplinary team approach for nutritional interventions conducted by specialist nurses in patients with advanced colorectal cancer undergoing chemotherapy: A clinical trial.
A multidisciplinary team approach for nutritional interventions conducted by specialist nurses in patients with advanced colorectal cancer undergoing chemotherapy: A clinical trial.
复制标题
由专科护士对接受化疗的晚期结直肠癌患者进行营养干预的多学科团队方法：一项临床试验。
DOI：
10.1097/md.0000000000007373
复制
发表时间：
2017-06
期刊：
影响因子：
1.6
通讯作者：
Wu XY
中科院分区：
文献类型：
--
作者：
Lin JX;Chen XW;Chen ZH;Huang XY;Yang JJ;Xing YF;Yin LH;Li X;Wu XY
营养干预对癌症患者的营养不良可能有帮助。然而，简明的干预建议仍然存在争议。因此，本研究的目的是报告由一个多学科的专科护士团队进行的营养干预，并探讨营养干预对癌症患者的影响。这项前瞻性临床试验研究招募了110名接受化疗的结直肠癌患者。患者入院后使用2002年营养风险筛查系统（NRS-2002）进行评估。将患者随机分为干预组和对照组各55例。对照组的患者接受正常饮食，而干预组的患者接受由专业护士，临床医生，营养师，家庭护理人员和患者自己组成的团队开发的个人食谱。比较两组患者在不同时间点的体重、血清白蛋白和前白蛋白水平。干预组患者体重、血清白蛋白和前白蛋白水平在营养干预前后差异有统计学意义（P <0.05）。 在对照组中，体重在普通饮食指导期间没有变化。化疗12个周期后血清白蛋白水平略有改善，与前白蛋白结果相似。营养干预后，干预组与对照组血清白蛋白和前白蛋白水平差异有统计学意义（P <0.05）。 然而，营养干预后，两组之间的体重差异无统计学意义（P> 0.05）。 由专科护士进行的营养干预的多学科团队方法改善了接受化疗的结直肠癌患者的前白蛋白水平，而体重没有变化。
Nutritional interventions for malnutrition in cancer patients can be helpful. However, concise intervention recommendations remain controversial. Thus, the aim of this study was to report on a nutrition intervention conducted by a multidisciplinary team of specialist nurses and to explore the effect of nutritional intervention on cancer patients. This prospective clinical trial study enrolled 110 colorectal cancer patients undergoing chemotherapy. The patients were evaluated upon admission using the 2002 Nutritional Risk Screening system (NRS-2002). The patients were randomly divided into intervention and control groups including 55 patients each. Patients in the control group were administered a normal diet, while those in the intervention group received individual recipes developed by a team of professional nurses, clinical doctors, dietitian, family caregivers, and the patients themselves. Patient weight and serum albumin and prealbumin levels were compared between the 2 groups at different time points. There was a significant difference in patient weight and serum albumin and prealbumin levels before and after nutrition intervention in the intervention group (P < .05). In the control group, weight did not change during ordinary diet guidance. Serum albumin level was slightly improved after 12 cycles of chemotherapy, similar to the prealbumin results. There were statistically significant differences in serum albumin and prealbumin levels between the intervention and control groups after nutrition intervention (P < .05). However, there was no statistically significant difference in weight between the groups after nutrition intervention (P > .05). A multidisciplinary team approach for nutrition intervention conducted by specialist nurses improved prealbumin levels in colorectal cancer patients undergoing chemotherapy, with no weight change.