Demographic aspects of allergic ocular diseases and evaluation of new criteria for clinical assessment of ocular allergy
Demographic aspects of allergic ocular diseases and evaluation of new criteria for clinical assessment of ocular allergy
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DOI：
10.1007/s00417-007-0697-z
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发表时间：
2008-02-01
影响因子：
2.7
通讯作者：
Kadonosono, Kazuaki
中科院分区：
文献类型：
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作者：
Uchio, Eiichi;Kimura, Ryoji;Kadonosono, Kazuaki
背景变应性眼病（AOD）的临床特点是种类繁多。临床评价标准不仅对于临床试验中的客观评估至关重要，而且对于AOD病因学方面的临床研究也至关重要。然而，目前还没有国际公认的标准，用于临床评价和分类的严重程度的AOD。我们建立了新的标准，并将其应用于许多情况下的AOD，并评估其实用性的临床目的。我们还研究了是否每一个临床实体的AOD [过敏性结膜炎（AC），特应性角膜结膜炎（AKC），春季角膜结膜炎（VKC）]可以区分这些criteria.Methods进行了前瞻性研究，以评估1079例AOD（439名男性和640名女性患者）的鉴别诊断。鉴别诊断AC、AKC或VKC。根据局部和全身临床表现对这些疾病进行诊断和分类。结果1079例患者中，季节性变应性结膜炎（SAC）、常年性变应性结膜炎（PAC）、AKC和VKC占876分别为81.2%、115例（10.6%）、47例（4.4%）和41例（3.8%）。每种疾病的平均年龄分别为52.9、56.1、25.7和16.6岁。SAC、PAC、AKC和VKC的临床总评分分别为1.54、2.13、3.72和12.68。两种疾病的所有组合的平均年龄和临床总评分显示显着differents.Conclusions这些结果表明，我们的新的临床分级系统可以分类，该系统是足够敏感的AOD的临床评估。对AOD的重新评估对于构建未来治疗AOD的策略至关重要，AOD由各种眼科疾病组成。
Background The clinical features of allergic ocular diseases (AOD) are characterized by their wide variety. Clinical evaluation criteria are essential not only for objective assessment in clinical trials, but also for clinical studies on etiological aspects of AOD. However, there have been no internationally established criteria for clinical evaluation and classification of the severity of AOD. We established new criteria and applied them to many cases of AOD, and evaluated their usefulness for clinical purposes. We also studied whether each clinical entity of AOD [allergic conjunctivitis (AC), atopic keratoconjunctivitis (AKC), and vernal keratoconjunctivitis (VKC)] can be distinguished by these criteria.Methods A prospective study was carried out to assess the differential diagnosis of 1079 patients with AOD (439 male and 640 female patients). Differential diagnosis of AC, AKC or VKC was made. These diseases were diagnosed and classified based on local and systemic clinical findings. Ten objective ocular clinical findings of conjunctival, limbal and corneal lesions were graded on a 4-point scale, and the total score, with a highest value of 30, was used as the clinical score.Results Among a total of 1079 cases, seasonal allergic conjunctivitis (SAC), perennial allergic conjunctivitis (PAC), AKC and VKC accounted for 876 (81.2%), 115 (10.6%), 47 (4.4%) and 41 (3.8%) respectively. The mean age in each disease was 52.9, 56.1, 25.7 and 16.6 years respectively. Total clinical score in SAC, PAC, AKC and VKC was 1.54, 2.13, 3.72 and 12.68 respectively. Both mean age and total clinical score in all combinations of two diseases showed significantly different results.Conclusions These results suggest that AOD can be classified by our new clinical grading system, and this system is sensitive enough for clinical evaluation of AOD. Re-evaluation of AOD is essential for constructing future strategies for the treatment of AOD, which are consists of various categories of ocular disorders.