Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults
Type 2 diabetes mellitus and cognitive decline in two large cohorts of community-dwelling older adults
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DOI：
10.1111/j.1532-5415.2008.01686.x
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发表时间：
2008-06-01
影响因子：
6.3
通讯作者：
Grodstein, Francine
中科院分区：
文献类型：
--
作者：
Okereke, Olivia I.;Kang, Jae H.;Grodstein, Francine
设计：前瞻性队列设置：社区。配对：医生健康研究II中的5,907名男性和6,326名女性(基线认知评估时的平均年龄分别为74.1岁和71.9岁)；553名男性和405名女性的糖尿病。测量：主要结果是一般认知(认知状态的电话访谈和全球平均五项测试)和语言记忆。结果：在调整后的线性回归模型中，糖尿病患者的所有结果的基线得分显著降低，且糖尿病持续时间越长，得分越低(P-趋势
OBJECTIVES: To relate diabetes mellitus (DM) status and duration to late-life cognitive impairment and decline in men and women.DESIGN: Prospective cohort.SETTING: Community.PARTICIPANTS: Five thousand nine hundred seven men in the Physicians' Health Study II and 6,326 women in the Women's Health Study (mean age 74.1 and 71.9, respectively, at baseline cognitive assessment); 553 men and 405 women had DM.MEASUREMENTS: Primary outcomes were general cognition (the Telephone Interview for Cognitive Status (TICS) and a global score averaging five tests) and verbal memory. All participants had second assessments approximately 2 years later; women had third assessments an average of 4 years later.RESULTS: In adjusted linear regression models, participants with DM had significantly lower baseline scores for all outcomes, and longer duration of DM was associated with lower scores (P-trends