Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis - A dose-response study
Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis - A dose-response study
复制标题
DOI：
10.1007/bf02213140
复制
发表时间：
1996-04-01
影响因子：
3.1
通讯作者：
Podda, M
中科院分区：
文献类型：
--
作者：
Crosignani, A;Battezzati, PM;Podda, M
牛磺熊去氧胆酸是一种高度亲水性的胆汁酸，可能对慢性胆汁淤积性肝病有治疗价值。我们对24例原发性胆汁性肝硬化患者进行了剂量反应研究，这些患者被随机分配接受500，1000或1500 mg每日牛磺熊去氧胆酸治疗6个月，胆汁中熊去氧胆酸的富集率在15%~ 48%之间，与剂量无关。三种剂量治疗后第一个月血清肝酶水平均显著下降，三种剂量之间无显著差异。尽管在1000和1500 mg/天的剂量下随着时间的推移进一步降低，但在给予两种较高剂量的患者中，血浆总胆固醇和HDL胆固醇显著降低，腹泻是唯一的副作用。总之，在原发性胆汁性肝硬化患者的长期研究中应使用约10 mg/kg体重/天的剂量的牛磺熊去氧胆酸。
Tauroursodeoxycholic acid, a highly hydrophilic bile acid, may be of therapeutic value for chronic cholestatic liver diseases, We performed a dose-response study on 24 patients with primary biliary cirrhosis who were randomly assigned to receive 500, 1000, or 1500 mg daily of tauroursodeoxycholic acid for six months, Biliary enrichment with ursodeoxycholic acid ranged from 15% to 48% and was not related with the dose, Serum liver enzyme levels decreased significantly after the first month of treatment with all the three doses, No significant difference among the three doses was found, although further reduction over time occurred with 1000 and 1500 mg daily, Plasma total and HDL cholesterol significantly decreased in patients administered the two higher doses, Diarrhea was the only side effect, In conclusion, a dose of about 10 mg/kg body wt/day of tauroursudeoxycholic acid should be used for long-term studies in patients with primary biliary cirrhosis.