Locus coeruleus MRI contrast is associated with cortical thickness in older adults.
Locus coeruleus MRI contrast is associated with cortical thickness in older adults.
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DOI：
10.1016/j.neurobiolaging.2020.12.019
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发表时间：
2021-04
影响因子：
4.2
通讯作者：
Mather M
中科院分区：
文献类型：
--
作者：
Bachman SL;Dahl MJ;Werkle-Bergner M;Düzel S;Forlim CG;Lindenberger U;Kühn S;Mather M
越来越多的证据表明去甲肾上腺素能蓝斑（LC）的神经元完整性对晚年认知很重要。不太了解的是LC完整性如何与认知的大脑相关性，如大脑结构。在这里，我们研究了皮质厚度之间的关系，并反映在老年人（n = 229）和年轻人（n = 67）的LC完整性的措施。使用在LC中产生高信号强度的磁共振成像序列，我们评估了LC和邻近脑桥参考组织的信号强度之间的对比度。使用Freesurfer软件套件定量皮质厚度。LC对比度与老年人的皮质厚度呈正相关，这种关联在顶叶、额叶和枕叶区域尤为突出。LC对比度与皮质厚度相关的脑区包括额顶叶网络的部分，这些部分与去甲肾上腺素调节的认知功能有关。这些发现为成年后期LC结构和皮质脑结构之间的联系提供了新的证据。
There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in older (n = 229) and younger adults (n = 67). Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The Freesurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood.
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影响因子：
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