Therapeutic and Prophylactic Applications of Bacteriophage Components in Modern Medicine
Therapeutic and Prophylactic Applications of Bacteriophage Components in Modern Medicine
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DOI：
10.1101/cshperspect.a012518
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发表时间：
2014-01-01
影响因子：
5.4
通讯作者：
Biswas, Biswajit
中科院分区：
文献类型：
--
作者：
Adhya, Sankar;Merril, Carl R.;Biswas, Biswajit
随着噬菌体与哺乳动物先天和适应性免疫系统的相互作用得到更好的描述，并且我们有能力识别和消除毒素和其他潜在有害的噬菌体基因产物，噬菌体疗法的潜力现在正在实现。早期使用噬菌体治疗的努力受到噬菌体纯化不足和噬菌体-细菌和噬菌体-人类关系知识有限的阻碍。然而，尽管在需要对照临床研究的国家中使用噬菌体作为抗菌疗法受到患者试验的高成本的阻碍，但它们作为疫苗的使用和噬菌体组分如溶菌酶或溶菌酶的使用已经发展到商业应用的程度。最近关于哺乳动物宿主与细菌和噬菌体微生物组之间密切联系的研究应该加速这一进展。
As the interactions of phage with mammalian innate and adaptive immune systems are better delineated and with our ability to recognize and eliminate toxins and other potentially harmful phage gene products, the potential of phage therapies is now being realized. Early efforts to use phage therapeutically were hampered by inadequate phage purification and limited knowledge of phage-bacterial and phage-human relations. However, although use of phage as an antibacterial therapy in countries that require controlled clinical studies has been hampered by the high costs of patient trials, their use as vaccines and the use of phage components such as lysolytic enzymes or lysozymes has progressed to the point of commercial applications. Recent studies concerning the intimate associations between mammalian hosts and bacterial and phage microbiomes should hasten this progress.