Development and reliability of the HAM-D/MADRS Interview: An integrated depression symptom rating scale
Development and reliability of the HAM-D/MADRS Interview: An integrated depression symptom rating scale
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DOI：
10.1016/j.psychres.2005.10.009
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发表时间：
2006-11-29
影响因子：
11.3
通讯作者：
Sublette, M. Elizabeth
中科院分区：
文献类型：
--
作者：
Iannuzzo, Rebecca W.;Jaeger, Judith;Sublette, M. Elizabeth
汉密尔顿抑郁量表（HAM-D）和蒙哥马利-安氏抑郁量表（MADRS）是两种广泛使用的抑郁量表，各有其独特的优势和研究局限性。尽管HAM-D量表很受欢迎，但它有限的敏感性和多维性一直受到批评。MADRS设计为对治疗变化敏感，更简短，更统一。MADRS的一个局限性是缺乏结构化访谈，这可能会影响可靠性。HAM-D和MADRS通常联合用作抑郁症试验的终点。我们设计了一个混合式问卷，允许同时管理MADRS和31个HAM-D项目。70例心境障碍患者（60例双相I型，10例重度抑郁症）进行了HAM-D/MADRS访谈（HMI）作为一个更大的研究的一部分。50例患者的HAM-D和MADRS的评定者间可靠性极佳（ICC = 0.97-0.98）。MADRS项目的可靠性（ICC = 0.86-0.97）高于没有使用结构化访谈的研究。7个HAM-D-31“非典型”症状的可靠性系数范围为0.77至0.95。HMI与全球临床不适量表高度相关。这是我们所知道的第一项研究，以调查结构化面试的可靠性，无论是MADRS或HAM-D-31。HMI提供了一种易于管理、可靠的抑郁严重程度评级方法，可提高研究结果的一致性和有效性。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
The Hamilton Rating Scale for Depression (HAM-D) and the Montgomery-angstrom sberg Depression Rating Scale (MADRS), two widely used depression scales, each have unique advantages and limitations for research. The HAM-D's limited sensitivity and multidimensionality have been criticized, despite the scale's popularity. The MADRS, designed to be sensitive to treatment changes, is briefer and more uniform. A limitation of the MADRS is the lack of a structured interview, which may affect reliability. The HAM-D and the MADRS are often used conjointly as endpoints in depression trials. We designed a hybrid questionnaire that allows administration of MADRS and 31 HAM-D items simultaneously. Seventy mood disorder patients (60 bipolar I, 10 major depressive disorder) were administered the HAM-D/MADRS Interview (HMI) as part of a larger study. Interrater reliability for 50 patients was excellent for the HAM-D and the MADRS (ICC = 0.97-0.98). MADRS item reliabilities (ICC = 0.86-0.97) were higher than obtained in studies that did not use a structured interview. Reliability coefficients for seven HAM-D-31 'atypical' symptoms ranged from 0.77 to 0.95. HMI was highly correlated with the Global Clinical Impressions Scale. This is the first study we know of to investigate the reliability of a structured interview of either the MADRS or of the HAM-D-31. The HMI provides an easily administered, reliable method of rating depression severity which may improve consistency and validity of study findings. (c) 2005 Elsevier Ireland Ltd. All rights reserved.