OBSERVER ERROR AND SAMPLING VARIABILITY TESTED IN EVALUATION OF HEPATITIS AND CIRRHOSIS BY LIVER BIOPSY
OBSERVER ERROR AND SAMPLING VARIABILITY TESTED IN EVALUATION OF HEPATITIS AND CIRRHOSIS BY LIVER BIOPSY
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DOI：
10.1007/bf02235164
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
BAGGENSTOSS, AH
中科院分区：
文献类型：
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作者：
SOLOWAY, RD;SCHOENFIELD, LJ;BAGGENSTOSS, AH
在50例慢性活动性肝病患者中，根据编码组织评估盲针肝活检后组织学评估肝炎和肝硬变的观察者和抽样误差。这是通过同一病理学家对相同标本的重复读取，通过对相同的肝硬变患者的连续活组织检查，以及通过从邻近肝脏区域同时进行多次活组织检查来完成的。观测者的误差很小。肝炎的个体组织学特征分级的符合率为90%，肝炎或肝硬变程度的重复性为94%。肝炎的抽样误差也很小，表明单针活检准确地反映了肝脏邻近区域炎症和坏死的类型和程度。相比之下，当在已知有病变的患者中寻求存在肝硬变时，抽样误差是相当大的，因为只有33%的病例通过同时或顺序活组织检查进行确认。
In 50 patients with chronic active liver disease, observer and sampling error in histologically evaluating hepatitis and cirrhosis after blind-needle biopsy of the liver was assessed from coded tissue. This was done by repeated readings of the same specimens by the same pathologist, by sequential biopsies from the same patients with cirrhosis, and by multiple simultaneous biopsies from adjacent areas of the liver. Observer error was small. The consistency of grading the individual histologic characteristics of hepatitis was 90%, and the reproducibility of the degree of either hepatitis or cirrhosis was 94%. Sampling error was also trivial in hepatitis, indicating that a single needle biopsy accurately reflects the type and degree of inflammation and necrosis in adjacent areas of the liver. By contrast, sampling error was of considerable magnitude when the presence of cirrhosis in patients known to have the lesion was sought, since confirmation by simultaneous or sequential biopsies was made in only 33% of the cases.