Blunted Cortisol Awakening Response in People at Ultra High Risk of Developing Psychosis
Blunted Cortisol Awakening Response in People at Ultra High Risk of Developing Psychosis
复制标题
DOI：
10.1016/j.schres.2014.06.041
复制
发表时间：
2014-09-01
影响因子：
4.5
通讯作者：
McGuire, Philip
中科院分区：
文献类型：
--
作者：
Day, Fern L.;Valmaggia, Lucia R.;McGuire, Philip
背景：压力在精神病的发病中起作用是一个共识，但确切的潜在机制仍不清楚。下丘脑-垂体-肾上腺（HPA）轴被认为是调节应激与精神病之间关系的重要因素，有证据表明应激激素皮质醇作为精神病风险的生物标志物具有潜在的作用。目的：我们通过检测精神病超高风险人群（UHR）的HPA轴及其与症状的关系来探讨这一假设。方法：对52例UHR和52例健康对照者进行研究。（HC; n = 42）的参与者进行了比较，两项措施的HPA轴功能：皮质醇响应觉醒和白天皮质醇release.Results：UHR参与者表现出迟钝的皮质醇觉醒反应相比，HC参与者。白天皮质醇水平没有组间差异被发现，也没有任何皮质醇措施和symptoms.Conclusions之间的关联：这些研究结果与以前的研究和神经生物学模型提出，压力和HPA轴参与精神病的发病，虽然他们提出了进一步的问题，这种参与的确切性质。(C)2014爱思唯尔有限公司版权所有。
Background: There is a consensus that stress plays a role in the onset of psychosis but the precise underlying mechanism remains unclear. The hypothalamic-pituitary-adrenal (HPA) axis is hypothesised to mediate the relationship between stress and psychosis and evidence indicates a potential role for the stress hormone cortisol as a biomarker of psychosis risk.Objective: We explored this hypothesis by examining the HPA axis in people at ultra-high risk (UHR) for psychosis and its relationship to symptoms.Method: UHR (n=52) and healthy control (HC; n = 42) participants were compared on two measures of HPA axis function: cortisol response to awakening and daytime cortisol release.Results: UHR participants displayed a blunted cortisol awakening response compared with HC participants. No group difference in daytime cortisol levels was found, nor were any associations between cortisol measures and symptoms.Conclusions: These findings are broadly consistent with previous studies and neurobiological models which propose that stress and the HPA axis are involved in the onset of psychosis, although they raise further questions regarding the precise nature of this involvement. (C) 2014 Elsevier B.V. All rights reserved.