A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice
A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice
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DOI：
10.7554/elife.22861
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发表时间：
2017-06-15
期刊：
影响因子：
7.7
通讯作者：
Hattar, Samer
中科院分区：
文献类型：
--
作者：
Chew, Kylie S.;Renna, Jordan M.;Hattar, Samer
视觉系统由两个主要的子系统组成，驱动有意识视觉的图像形成回路和用于诸如昼夜光诱导等行为的非图像形成回路。虽然在历史上被认为是不重叠的，但最近的证据已经揭示了这些子系统之间的串扰。在这里，我们研究了共同的发展机制。我们揭示了光在生物钟成熟中的前所未有的作用，并发现本质光敏视网膜神经节细胞（ipRGC）对这一细化过程至关重要。此外，ipRGC调节视网膜波不依赖于光，并且ipRGC的子集的发育消融破坏视网膜膝状体投射的眼睛特异性分离。具体地，ipRGC的子集，包括200个细胞，并且其投射到视网膜内和脑中的昼夜节律中心，足以介导这两个发育过程。因此，ipRGC的该子集构成神经网络中的共享节点，其介导昼夜节律钟的光依赖性成熟和视网膜膝状体投射的光独立性细化。
The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment. While historically considered non-overlapping, recent evidence has uncovered crosstalk between these subsystems. Here, we investigated shared developmental mechanisms. We revealed an unprecedented role for light in the maturation of the circadian clock and discovered that intrinsically photosensitive retinal ganglion cells (ipRGCs) are critical for this refinement process. In addition, ipRGCs regulate retinal waves independent of light, and developmental ablation of a subset of ipRGCs disrupts eye-specific segregation of retinogeniculate projections. Specifically, a subset of ipRGCs, comprising 200 cells and which project intraretinally and to circadian centers in the brain, are sufficient to mediate both of these developmental processes. Thus, this subset of ipRGCs constitute a shared node in the neural networks that mediate light-dependent maturation of the circadian clock and light-independent refinement of retinogeniculate projections.