CONCURRENT CHEMOTHERAPY - RADIOTHERAPY FOR LIMITED SMALL-CELL LUNG-CARCINOMA - A SOUTHWEST ONCOLOGY GROUP-STUDY
CONCURRENT CHEMOTHERAPY - RADIOTHERAPY FOR LIMITED SMALL-CELL LUNG-CARCINOMA - A SOUTHWEST ONCOLOGY GROUP-STUDY
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DOI：
10.1200/jco.1990.8.5.892
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发表时间：
1990-05-01
影响因子：
45.3
通讯作者：
KUEBLER, JP
中科院分区：
文献类型：
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作者：
MCCRACKEN, JD;JANAKI, LM;KUEBLER, JP
西南肿瘤组（SWOG）进行了一项II期研究，以探索初始的，同时使用顺铂，依托泊苷（VP-16）和长春新碱的放射治疗在有限阶段的小细胞肺癌的效率和毒性。给予顺铂、VP-16和长春新碱化疗两个疗程，同时对原发性肿瘤进行放射治疗（XRT），总剂量为4，500 cGy。所有患者均接受选择性脑XRT，同时接受第三个疗程的顺铂/VP-16治疗。在初始诱导化疗/XRT程序后，给予由长春新碱、甲氨蝶呤和VP-16交替阿霉素（阿霉素; Adria Laboratories，哥伦布，OH）和环磷酰胺组成的巩固化疗12周。完全缓解的患者停止所有治疗。在154名合格的接受治疗的患者中，完全缓解率为56%，部分缓解率为27%。中位生存期为17.5个月，从治疗开始后4年的估计生存率为30%。联合治疗的毒性是可接受的，主要毒性是中度至重度白细胞减少症和轻度放射性食管炎。该治疗方案的结果似乎上级于我们组以前报道的任何治疗方案，并与文献中的结果进行了比较。
The Southwest Oncology Group (SWOG) has conducted a phase II study to explore the efficiency and toxicity of initial, concurrent use of radiation therapy with cisplatin, etoposide (VP-16), and vincristine in limited-stage small-cell carcinoma of the lung. Two courses of cisplatin, VP-16, and vincristine chemotherapy were given with concurrent radiotherapy (XRT) to the primary tumor to a total dose of 4,500 cGy. Elective brain XRT was given to all patients concurrent with a third course of cisplatin/VP-16 therapy. Consolidation chemotherapy consisting of vincristine, methotrexate, and VP-16 alternating with Adriamycin (doxorubicin; Adria Laboratories, Columbus, OH) and cyclophosphamide, was given for 12 weeks following the initial induction chemotherapy/XRT program. Patients with a complete response had all therapy discontinued. Among 154 eligible patients treated, the complete response rate was 56%, with a partial response rate of 27%. The median survival is 17.5 months with an estimated 30% survival rate at 4 years from initiation of treatment. Combined modality toxicities were acceptable with the predominant toxicity being moderate to severe leukopenia and mild radiation esophagitis. The results of this treatment program appear superior to any previously reported by our group and compare favorably to those in the literature at large.