Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study.
Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study.
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DOI：
10.1186/s12967-016-0866-0
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发表时间：
2016-04-30
影响因子：
7.4
通讯作者：
Li WD
中科院分区：
文献类型：
--
作者：
Wei F;Sun N;Cai C;Feng S;Tian J;Shi W;Xu W;Wang Y;Yang X;Li WD
在过去的几十年中，高尿酸血症的患病率急剧增加。研究表明尿酸是高血压的独立危险因素，但没有充分控制其他已知的危险因素。我们在一个全面的中国高中动态队列中探索了这种关系。为探讨血尿酸（SUA）水平与高血压的关系，我们对3591例无高血压的动态队列进行了6年回顾性研究（2006-2011年）。每例受试者首次记录的高血压为索引事件。考克斯比例风险模型评估SUA与高血压之间的关系。Kaplan-Meier生存分析比较了具有每个SUA四分位数的个体之间的高血压发病率。生成受试者工作特征曲线，以获得曲线下面积，作为从SUA水平预测高血压的指标。高血压的累积患病率为20.7%。高尿酸血症的患病率为17.5%。考克斯回归分析显示，与最低SUA四分位数相比（<4.69 mg/dl），4.69-5.58、5.58-6.52和≥6.52 mg/dl四分位数产生风险比（95%置信区间）分别为1.652（1.265-2.156）、2.195（1.705-2.825）和3.058（2.399-3.899）。高尿酸血症患者的高血压累积发病率始终高于SUA水平正常者。Kaplan-Meier生存分析显示，高尿酸血症以剂量依赖性方式预测高血压的发生率较高：高血压发作在SUA四分位数之间存在显著差异。在我们的队列中，SUA水平与高血压的发病率显著且独立相关。我们的研究结果，控制已知的危险因素，表明SUA水平是一个独立的高血压的危险因素，并可能是一个有用的指标高血压。本文的在线版本（doi：10.1186/s12967-016-0866-0）包含补充材料，可供授权用户使用。
The prevalence of hyperuricemia has increased dramatically during the past several decades. Studies indicating uric acid is an independent risk factor for hypertension did not sufficiently control for other known risk factors. We explored this relationship in a comprehensive Chinese senior dynamic cohort. To investigate the relationship between serum uric acid (SUA) levels and hypertension, we carried out a 6-year retrospective study (2006–2011) in a dynamic cohort with 3591 subjects free of hypertension. The first occasion of documented hypertension per subject was the index event. A Cox proportional hazards model assessed the relationship between SUA and hypertension. Kaplan–Meier survival analysis compared incidence of hypertension among individuals with each SUA quartile. Receiver operating characteristic curves were generated to obtain the area under the curve as a prediction of hypertension from SUA levels. The cumulative prevalence of hypertension in our cohort was 20.7 %. The prevalence of hyperuricemia was 17.5 %. Cox regression analysis showed that, compared with the lowest SUA quartile (<4.69 mg/dl), the 4.69–5.58, 5.58–6.52, and ≥6.52 mg/dl quartiles yielded hazard ratios (95 % confidence intervals) for hypertension of 1.652 (1.265–2.156), 2.195 (1.705–2.825), and 3.058 (2.399–3.899), respectively. Cumulative incidence of hypertension was consistently higher among individuals with hyperuricemia than among those with normal SUA levels. A Kaplan–Meier survival analysis showed that hyperuricemia predicted higher incidences of hypertension in a dose-dependent manner: hypertension onset significantly differed across SUA quartiles. SUA levels were significantly and independently associated with incidence of hypertension in our cohort. Our results, controlling for known risk factors, suggest that SUA level is an independent risk factor for hypertension and could be a useful indicator of hypertension. The online version of this article (doi:10.1186/s12967-016-0866-0) contains supplementary material, which is available to authorized users.