Nonbasic, room temperature, palladium-catalyzed coupling of aryl and alkenyl iodides with boronic acids mediated by copper(I) thiophene-2-carboxylate (CuTC).
Nonbasic, room temperature, palladium-catalyzed coupling of aryl and alkenyl iodides with boronic acids mediated by copper(I) thiophene-2-carboxylate (CuTC).
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DOI：
10.1021/ol010060p
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发表时间：
2001-06
期刊：
影响因子：
5.2
通讯作者：
C. Savarin;L. S. Liebeskind
中科院分区：
文献类型：
--
作者：
C. Savarin;L. S. Liebeskind
[反应：见正文]一个新的协议，钯催化，铜介导的偶联芳基和烯基碘与硼酸的描述。作为众所周知的和广泛使用的Suzuki交叉偶联的替代方案，该反应在室温下在不存在碱的情况下发生，并且应该特别适用于构建带有碱敏感和热敏部分的底物。
[reaction: see text] A new protocol for the palladium-catalyzed, copper-mediated coupling of aryl and alkenyl iodides with boronic acids is described. As an alternative to the well-known and widely used Suzuki cross-coupling, this reaction occurs in the absence of a base at room temperature and should be particularly useful for the construction of substrates bearing base-sensitive and thermally sensitive moieties.