Tissue Doppler and strain imaging for evaluating tissue elasticity of breast lesions
Tissue Doppler and strain imaging for evaluating tissue elasticity of breast lesions
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DOI：
10.1016/j.acra.2006.12.016
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发表时间：
2007-05-01
影响因子：
4.8
通讯作者：
Fischer, Thomas
中科院分区：
文献类型：
--
作者：
Thomas, Anke;Warm, Mathias;Fischer, Thomas
基本原理和目标。声弹性成像描绘了组织的固有弹性特性，其特征在于为实现组织变形而施加的应变以及组织变形发生的速度。本研究旨在探讨是否可以通过将 B 型成像与组织多普勒成像 (TDI) 相结合以及组织应变成像 (TSI) 的离线分析来提高 B 型超声 (US) 的特异性。材料和方法。使用线性换能器（9 MHz，Aplio，Toshiba，Otawara，Japan）对 50 名女性进行了超声检查，其中 25 名患有恶性，25 名患有良性局灶性乳腺病变。病变的 B 模式 US 视图覆盖有颜色编码的 TDI 信息，并计算面积商（AQ = 面积 B 模式视图/面积 TDI）。 TSI 视图是根据源数据离线重建的。这是通过在目标病变中放置感兴趣区域 (ROI) 并以颜色编码显示信息来完成的。此外，使用对应于 BI-RADS 类别的 1-5 等级来评估组织弹性。在 ROI 中确定最大应变（应变因子，SF）。所有患者还接受了乳房 X 光检查。计算敏感性和特异性，并使用 Wilcoxon 检验进行统计分析。结果。 B 型超声的敏感性/特异性为 96%/68%，B 型超声和乳房 X 光检查组合的敏感性/特异性为 100%/40%，TSI 的敏感性/特异性为 96%/80%。良性和恶性病变的 AQ 存在显着差异 (p = .00008)，SF 也存在显着差异 (p = .0004)。读者认为 TSI 是一种可行的技术。结论。基于应变因子量化的弹性评估可改善局灶性乳腺病变的特征，尤其是 BI-RADS 3 和 4 病变的区分。令人惊讶的是，利用简单的 TDI 技术在表征乳腺病变方面获得了显着的结果，显示恶性病例中的组织移位较低。
Rationale and Objectives. Sonoelastography depicts the intrinsic elastic properties of a tissue which are characterized by the strain applied to achieve tissue deformation and the velocity at which tissue deformation occurs. The present study served to investigate whether the specificity of B-mode ultrasound (US) can be improved by combining B-mode imaging with tissue Doppler imaging (TDI) and offline analysis of tissue strain imaging (TSI).Materials and Methods. Fifty women, 25 with malignant and 25 with benign focal breast lesions, were examined by US with a linear transducer (9 MHz, Aplio, Toshiba, Otawara, Japan). B-mode US views of the lesions were overlaid with color-coded TDI information and area quotients (AQ = area B-mode view/area TDI) were calculated. TSI views were reconstructed offline from the source data. This was done by placing a region of interest (ROI) in the target lesion and color-encoded display of the information. In addition, tissue elasticity was evaluated using a scale of 1-5 corresponding to the BI-RADS categories. Maximum strain (strain factor, SF) was determined in the ROI All patients also underwent mammography. Sensitivities and specificities were calculated and statistical analysis was performed using Wilcoxon's test.Results. Sensitivity/specificity was 96%/68% for B-mode US, 100%/40% for combined B-mode US and mammography, and 96%/80% for TSI. The AQ of benign and malignant lesions was significantly different (p = .00008) as was the difference in SF (p = .0004). The readers considered TSI a feasible technique.Conclusion. Evaluation of elasticity based on the quantification of strain factors improves characterization of focal breast lesions, especially the differentiation of BI-RADS 3 and 4 lesions. Surprisingly, significant results in characterizing breast lesions were obtained with the simple technique of TDI, showing a lower tissue displacement in malignant cases.