Cytogenetic studies in preleukaemia using the G-banding staining technique.
Cytogenetic studies in preleukaemia using the G-banding staining technique.
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使用 G 带染色技术对白血病前期进行细胞遗传学研究。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
C. Gardikas
中科院分区：
文献类型：
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作者：
A. Panani;A. Papayannis;K. Kyrkou;C. Gardikas
应用G显带技术对15例白血病前期患者进行了细胞遗传学研究。9例患者核型完全正常，6例患者出现各种染色体异常，包括数量异常(5例三体)和结构异常(1例缺失，1例标记染色体)。C组6例，A组3例。G显带技术显示C三体影响8号染色体(2例)和9号染色体(3例)，同时发现1例11号染色体(11q-)缺失，1例标记染色体，其起源为3号和6号染色体易位。
15 patients with preleukaemia were cytogenetically studied during the preleukaemic state by using the G-banding staining technique. It was found that 9 patients had a completely normal karyotype, while the other 6 showed various chromosomal abnormalities, numerical (trisomies in 5 cases) and structural (deletion in 1 case and a marker chromosome in 1 case). The abnormalities concerned group C in all 6 cases, while group A was involved in 3 cases. G-banding technique revealed that trisomy C affected the chromosomes nos 8 (2 cases) and 9 (3 cases); also a deleted chromosome 11 (11q-) was identified in 1 case and a marker chromosome in 1, the origin of which was established as a translocation between chromosomes 3 and 6. The abnormalities of group A concerned chromosome no 3. The abnormalities found in our cases, using the G-banding technique, were similar to those described in acute leukaemia.