Centromedian thalamic nucleus with or without anterior thalamic nucleus deep brain stimulation for epilepsy in children and adults: A retrospective case series.
Centromedian thalamic nucleus with or without anterior thalamic nucleus deep brain stimulation for epilepsy in children and adults: A retrospective case series.
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Centromedian丘脑核对儿童和成人的癫痫症具有或没有前丘脑深脑刺激：一个回顾性病例系列。
DOI：
10.1016/j.seizure.2020.11.012
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Lundstrom BN
中科院分区：
文献类型：
--
作者：
Alcala-Zermeno JL;Gregg NM;Wirrell EC;Stead M;Worrell GA;Van Gompel JJ;Lundstrom BN
中核（CM）和丘脑前核（ANT）分别是治疗全身性和局灶性耐药癫痫（DRE）的深部脑刺激（DBS）靶点。我们报告了一个单中心回顾性病例系列，包括16名患有DRE的儿童和成人，他们接受CM合并ANT（69%）或CM不同时ANT DBS（31%）。比较DBS前后癫痫发作频率、癫痫严重程度、生活满意度和睡眠质量。基线中位发作频率为323次/月（IQR， 71-563 sz/月）。中位随访时间为80个月（IQR 37 ~ 97个月）。癫痫发作频率中位数降低58% （IQR 13 - 87%, p = 0.002）。10例患者（63%）报告癫痫发作频率降低≥50%。CM + ANT组与单独CM组的中位数癫痫发作频率减少和应答率无显著差异。癫痫发作严重程度和生活满意度显著提高。3例患者（19%）出现器械相关副作用，其中2例（12.5%）需要手术干预。在具有全身性、多灶性、后发性和定位不良的DRE的儿童和成人异质人群中，CM伴或不伴ANT DBS是可行的、相对安全的，并且与减少癫痫发作频率和严重程度以及提高生活满意度相关。
The centromedian (CM) and anterior nucleus of the thalamus (ANT) are deep brain stimulation (DBS) targets for management of generalized, and focal drug resistant epilepsy (DRE), respectively. We report on a single center retrospective case series of 16 children and adults with DRE who underwent CM with simultaneous ANT (69 %) or CM without simultaneous ANT DBS (31 %). Seizure frequency, epilepsy severity, life satisfaction, and quality of sleep before and after DBS were compared. Baseline median seizure frequency was 323 seizures per month (IQR, 71–563 sz/mo). Median follow up time was 80 months (IQR 37–97 mo). Median seizure frequency reduction was 58 % (IQR 13–87 %, p = 0.002). Ten patients (63 %) reported ≥50 % seizure frequency reduction. Median seizure frequency reduction and responder rate were not significantly different for CM + ANT versus CM only. Seizure severity and life satisfaction were significantly improved. Three patients (19 %) developed device-related side effects, 2 of them (12.5 %) required surgical intervention. In a heterogenous population of children and adults with generalized, multifocal, posterior onset, and poorly localized DRE, CM with or without ANT DBS is feasible, relatively safe and is associated with reduced seizure frequency and severity, as well as improved life satisfaction.
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影响因子：
9.9
作者：
Salanova, Vicenta;Witt, Thomas;Fisher, Robert
通讯作者：
Fisher, Robert
影响因子：
5.6
作者：
Fisher, Robert;Salanova, Vicenta;Graves, Nina
通讯作者：
Graves, Nina
DOI：
10.1212/con.0000000000000708
发表时间：
2019-04-01
期刊：
Continuum (Minneapolis, Minn.)
影响因子：
--
作者：
Noe, Katherine
通讯作者：
Noe, Katherine
影响因子：
5.6
作者：
Scheffer IE;Berkovic S;Capovilla G;Connolly MB;French J;Guilhoto L;Hirsch E;Jain S;Mathern GW;Moshé SL;Nordli DR;Perucca E;Tomson T;Wiebe S;Zhang YH;Zuberi SM
通讯作者：
Zuberi SM
影响因子：
5.6
作者：
Kwan, Patrick;Arzimanoglou, Alexis;French, Jacqueline
通讯作者：
French, Jacqueline