Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles.
Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles.
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DOI：
10.1039/c5nr05264e
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发表时间：
2015-12-07
期刊：
影响因子：
6.7
通讯作者：
Kim J
中科院分区：
文献类型：
--
作者：
Kang H;Mintri S;Menon AV;Lee HY;Choi HS;Kim J
纳米粒子（NPs）被认为是一种有前途的工具，在诊断和治疗。治疗诊断纳米颗粒在单一实体内具有靶向成像和药物递送的组合特性。虽然治疗诊断NP的分类是基于其结构和组成，但NP的药代动力学受到治疗诊断NP的理化性质以及给药途径的显著影响。因此，改变的药代动力学改变了NP的药效学功效和毒性。虽然治疗诊断纳米粒子在纳米医学和生物医学应用中有很大的希望，但对纳米粒子的生物分布和不良反应的机制仍然缺乏了解。为了更好地了解纳米粒的诊断和治疗功能，本文综述了影响治疗诊断纳米粒的药代动力学，药效学和毒理学的因素，沿着几种发展新的诊断和治疗模式的策略。
Nanoparticles (NPs) are considered a promising tool in both diagnosis and therapeutics. Theranostic NPs possess the combined properties of targeted imaging and drug delivery within a single entity. While the categorization of theranostic NPs is based on their structure and composition, the pharmacokinetics of NPs are significantly influenced by the physicochemical properties of theranostic NPs as well as the routes of administration. Consequently, altered pharmacokinetics modify the pharmacodynamic efficacy and toxicity of NPs. Although theranostic NPs hold great promise in nanomedicine and biomedical applications, a lack of understanding persists on the mechanisms of the biodistribution and adverse effects of NPs. To better understand the diagnostic and therapeutic functions of NPs, this review discusses the factors that influence the pharmacokinetics, pharmacodynamics and toxicology of theranostic NPs, along with several strategies for developing novel diagnostic and therapeutic modalities.