Diagnostic imaging in patients with retinitis pigmentosa.
Diagnostic imaging in patients with retinitis pigmentosa.
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DOI：
10.2152/jmi.59.1
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Y. Mitamura;Sayaka Mitamura-Aizawa;Toshihiko Nagasawa;Takashi Katome;H. Eguchi;T. Naito
中科院分区：
文献类型：
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作者：
Y. Mitamura;Sayaka Mitamura-Aizawa;Toshihiko Nagasawa;Takashi Katome;H. Eguchi;T. Naito
视网膜色素变性是一种进行性遗传性视网膜疾病，由于视网膜光感受器和视网膜色素上皮(RPE)的退化导致患者视功能下降。在近视的末期，黄斑中心凹的光感受器的退化降低了中心视力，近视是发达国家后天性失明的主要原因之一。因此，黄斑区光感受器的形态和功能评估可用于评估RP患者的残余视网膜功能。光学相干断层扫描(OCT)是一种成熟的原位检查视网膜结构的方法。光感受器内/外节段(IS/OS)连接在OCT上观察到是一条明显的高反射线。OCT图像中IS/OS连接的存在对于正常的视觉功能是必不可少的。眼底自发荧光(Faf)是脂褐素在RPE细胞内积聚的结果，已被用来研究RPE和视网膜功能。超过一半的RP患者有异常高密度的黄斑旁Faf环(AF环)。房颤环代表了功能正常和功能失调的视网膜之间的边界。在这篇综述中，我们将对视网膜色素变性眼部影像诊断的最新进展进行综述。
Retinitis pigmentosa (RP) is a progressive inherited retinal disease, and patients with RP have reduced visual function caused by a degeneration of the photoreceptors and retinal pigment epithelium (RPE). At the end stage of RP, the degeneration of the photoreceptors in the fovea reduces central vision, and RP is one of the main causes of acquired blindness in developed countries. Therefore, morphological and functional assessments of the photoreceptors in the macula area can be useful in estimating the residual retinal function in RP patients. Optical coherence tomography (OCT) is a well-established method of examining the retinal architecture in situ. The photoreceptor inner/outer segment (IS/OS) junction is observed as a distinct, highly reflective line by OCT. The presence of the IS/OS junction in the OCT images is essential for normal visual function. Fundus autofluorescence (FAF) results from the accumulation of lipofuscin in the RPE cells and has been used to investigate RPE and retinal function. More than one-half of RP patients have an abnormally high density parafoveal FAF ring (AF ring). The AF ring represents the border between functional and dysfunctional retina. In this review, we shall summarize recent progress on diagnostic imaging in eyes with RP.