Cutting edge: MHC class II-restricted killing in vivo during viral infection
Cutting edge: MHC class II-restricted killing in vivo during viral infection
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DOI：
10.4049/jimmunol.174.2.614
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发表时间：
2005-01-15
影响因子：
4.4
通讯作者：
Welsh, RM
中科院分区：
文献类型：
--
作者：
Jellison, ER;Kim, SK;Welsh, RM
II类限制性CD4 T细胞介导的靶细胞杀伤先前已在体外但未在体内记录。在这项研究中，我们证明了CD4依赖的MHC II类限制性杀伤淋巴细胞性脉络丛脑膜炎病毒感染的小鼠体内使用体内细胞毒性试验，功能II类表达B细胞为目标。
Class II-restricted CD4 T cell-mediated killing of target cells has previously been documented in vitro but not in vivo. In this study, we demonstrate CD4-dependent MHC class II-restricted killing in lymphocytic choriomeningitis virus-infected mice in vivo using an in vivo cytotoxicity assay that features class II-expressing B cells as targets.