Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: results of the Dietary Intervention Study in Children follow-up study.
Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: results of the Dietary Intervention Study in Children follow-up study.
复制标题
DOI：
10.1158/1055-9965.epi-09-1259
复制
发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Barton BA
中科院分区：
文献类型：
--
作者：
Dorgan JF;Liu L;Klifa C;Hylton N;Shepherd JA;Stanczyk FZ;Snetselaar LG;Van Horn L;Stevens VJ;Robson A;Kwiterovich PO Jr;Lasser NL;Himes JH;Pettee Gabriel K;Kriska A;Ruder EH;Fang CY;Barton BA
青少年的饮食被假设会影响乳腺癌的风险。我们评估了降低青春期女孩脂肪摄入量的干预措施对与成年人乳腺癌风险相关的生物标志物的长期影响。对230名参加儿童饮食干预研究（DISC）的女孩进行了一项随访研究，其中健康的青春期前8-10奥尔兹被随机分配到常规护理或促进减脂饮食的行为干预。参与者在随访时年龄在25-29岁之间。所有统计学显著性检验均为双侧检验。在随访时未考虑饮食的分析中，唯一具有统计学意义的治疗组差异是干预组参与者的骨矿物质含量（BMC）高于常规护理组参与者;他们的平均BMC分别为2，444 g和2，377 g。调整当前饮食后，干预组的骨密度和黄体期血清雌二醇浓度也有统计学显著性升高。在未校正或校正分析中，治疗组之间的血清孕酮浓度和乳腺密度无差异。结果不支持这一假设，即在青春期消费低脂肪饮食通过影响随后的血清雌二醇和孕酮水平，乳腺密度或BMD降低乳腺癌的风险。需要进一步的研究来澄清青少年饮食与乳腺癌风险的关系，并确定本文报道的结果是否针对DISC干预或更广泛地适用。
Adolescent diet is hypothesized to influence breast cancer risk. We evaluated the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults. A follow-up study was conducted of 230 girls who participated in the Dietary Intervention Study in Children (DISC), in which healthy, prepubertal 8-10 year olds were randomly assigned to usual care or to a behavioral intervention that promoted a reduced fat diet. Participants were 25-29 years old at follow-up visits. All tests of statistical significance are two-sided. In analyses that did not take account of diet at the time of the follow-up visit, the only statistically significant treatment group difference was higher bone mineral content (BMC) in intervention group participants compared to usual care group participants; their mean BMCs were 2,444g and 2,377g, respectively. After adjustment for current diet, the intervention group also had statistically significantly higher bone mineral density and luteal phase serum estradiol concentrations. Serum progesterone concentrations and breast density did not differ by treatment group in unadjusted or adjusted analyses. Results do not support the hypothesis that consumption of a lower fat diet during adolescence reduces breast cancer risk via effects on subsequent serum estradiol and progesterone levels, breast density or BMD. Additional research is needed to clarify the association of adolescent diet with breast cancer risk and to determine if the results reported here are specific to the DISC intervention or more broadly applicable.