Bioaccumulation of psychoactive pharmaceuticals in fish in an effluent dominated stream
Bioaccumulation of psychoactive pharmaceuticals in fish in an effluent dominated stream
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DOI：
10.1016/j.watres.2017.08.018
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发表时间：
2017-11-01
期刊：
影响因子：
12.8
通讯作者：
Randak, Tomas
中科院分区：
文献类型：
--
作者：
Grabicova, Katerina;Grabic, Roman;Randak, Tomas
污水处理厂(STP)处理后的污水是进入水环境的活性药物成分(API)的主要来源。11种选定的精神活性药物(西酞普兰、氯米帕明、氟哌啶醇、羟基锌、左旋丙嗪、米安色林、米氮平、帕罗西汀、舍曲林、曲马多和文拉法辛)在Zivny Stream(捷克共和国布兰尼斯河的支流)中进行了生物积累研究，这是一条受到Prachatice STP出水高度影响的小河流。在11种药物中，有6种是在抓取水样和被动采样器中检测到的。所有药物都是在暴露在溪流中一段规定时间的鱼中发现的。所选药物含量最高的器官是肝脏和肾脏；而在暴露的鱼的大脑中只检测到一种药物(舍曲林)。鱼类血浆和肌肉样本不足以揭示暴露情况，因为点击次数远远低于肝脏或肾脏。以生物蓄积系数(BAF)=500为标准，西酞普兰、米安色林、米氮平和舍曲林可被归类为潜在的生物蓄积化合物。综合被动采样器和鱼的肝或肾组织样本的数据在检测目标化合物方面是互补的，同时有助于区分生物浓缩和生物积累。(C)2017爱思唯尔有限公司。
The treated effluent from sewage treatment plants (STP) is a major source of active pharmaceutical ingredients (APIs) that enter the aquatic environment. Bioaccumulation of 11 selected psychoactive pharmaceuticals (citalopram, clomipramine, haloperidol, hydroxyzine, levomepromazine, mianserin, mirtazapine, paroxetine, sertraline, tramadol and venlafaxine) was examined in Zivny Stream (tributary of the Blanice River, the Czech Republic), which is a small stream highly affected by effluent from the Prachatice STP. Six of the 11 pharmaceuticals were detected in grab water samples and in passive samplers. All pharmaceuticals were found in fish exposed to the stream for a defined time. The organs with highest presence of the selected pharmaceuticals were the liver and kidney; whereas only one pharmaceutical (sertraline) was detected in the brain of exposed fish. Fish plasma and muscle samples were not adequate in revealing exposure because the number of hits was much lower than that in the liver or kidney. Using the criterion of a bioaccumulation factor (BAF) >= 500, citalopram, mianserin, mirtazapine and sertraline could be classified as potential bioaccumulative compounds. In combination, data from integrative passive samplers and fish liver or kidney tissue samples were complimentary in detection of target compounds and simultaneously helped to distinguish between bioconcentration and bioaccumulation.(C) 2017 Elsevier Ltd. All rights reserved.