Mechanisms of mixed-lineage leukemia.
Mechanisms of mixed-lineage leukemia.
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DOI：
10.2217/ijh.13.20
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发表时间：
2013-06-01
影响因子：
--
通讯作者：
Muntean AG
中科院分区：
文献类型：
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作者：
Muntean AG
我们对白血病遗传决定因素的理解的进步已经转化为更好的治疗选择，并提高了急性髓细胞和急性淋巴细胞白血病患者的生存率。然而，一些白血病，如携带11q23（MLL）易位的白血病，导致具有相对较差预后的侵袭性疾病，尽管有诸如异基因造血干细胞移植的改进的治疗。本文将简要回顾野生型MLL在正常造血过程中的功能和调控，同时重点介绍我们对MLL白血病分子机制的最新研究进展。将讨论MLL相关白血病中涉及的转录靶点、协作信号通路和分子机制，以及如何利用这些来对这种疾病进行更个性化的治疗。
Advances in our understanding of the genetic determinants of leukemia have translated to better treatment options and improved survival of patients with acute myeloid and acute lymphoid leukemia. However, some leukemias, such as those bearing 11q23 (MLL) translocations, result in aggressive diseases with a relatively poor prognosis, despite improved treatments such as allogeneic hematopoietic stem cell transplantation. This article will briefly review the functions and regulation of wild-type MLL during normal hematopoiesis, while focusing on recent advances in our understanding of the molecular mechanisms governing MLL leukemias. The transcriptional targets, cooperating signaling pathways and molecular machinery involved in MLL-associated leukemias will be discussed, as well as how these may be harnessed for more personalized treatment of this disease.