Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care
Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care
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DOI：
10.1038/s41598-018-23940-z
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发表时间：
2018-04-04
影响因子：
4.6
通讯作者：
Collins, Lisa M.
中科院分区：
文献类型：
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作者：
Anderson, Katharine L.;O'Neill, Dan G.;Collins, Lisa M.
骨关节炎是兽医学诊断中最常见的关节疾病，对犬类福利构成相当大的挑战。本研究旨在调查英国初级兽医护理犬患阑尾骨关节炎的患病率、持续时间和危险因素。VetCompass （TM）项目收集了参加英国初级保健兽医实践的狗的临床数据。该研究包括2013年期间接受兽医护理的所有VetCompass （TM）狗。使用多种搜索策略确定候选骨关节炎病例。根据案例定义手动评估随机子集。在455,557只研究犬中，确定了16,437例候选骨关节炎病例；人工检查6104例（37%），确诊病例4196例（69%）。对确诊病例提取了人口统计学、临床症状、病程和管理方面的额外数据。估计每年阑尾骨关节炎的患病率为2.5% (CI95: 2.4-2.5%)，相当于每年约有20万只英国受影响的狗。与骨关节炎诊断相关的风险因素包括品种（如拉布拉多、金毛寻回犬）、有保险、绝育、体重较高和年龄超过8岁。持续时间计算试验表明，骨关节炎影响了11.4%的受影响个体的寿命，这进一步证明了骨关节炎在个体和种群水平上对犬类福利的重大影响。
Osteoarthritis is the most common joint disease diagnosed in veterinary medicine and poses considerable challenges to canine welfare. This study aimed to investigate prevalence, duration and risk factors of appendicular osteoarthritis in dogs under primary veterinary care in the UK. The VetCompass (TM) programme collects clinical data on dogs attending UK primary-care veterinary practices. The study included all VetCompass (TM) dogs under veterinary care during 2013. Candidate osteoarthritis cases were identified using multiple search strategies. A random subset was manually evaluated against a case definition. Of 455,557 study dogs, 16,437 candidate osteoarthritis cases were identified; 6104 (37%) were manually checked and 4196 (69% of sample) were confirmed as cases. Additional data on demography, clinical signs, duration and management were extracted for confirmed cases. Estimated annual period prevalence (accounting for subsampling) of appendicular osteoarthritis was 2.5% (CI95: 2.4-2.5%) equating to around 200,000 UK affected dogs annually. Risk factors associated with osteoarthritis diagnosis included breed (e.g. Labrador, Golden Retriever), being insured, being neutered, of higher bodyweight and being older than eight years. Duration calculation trials suggest osteoarthritis affects 11.4% of affected individuals' lifespan, providing further evidence for substantial impact of osteoarthritis on canine welfare at the individual and population level.