THE CLOTTING OF FIBRINOGEN .1. THE LIBERATION OF PEPTIDE MATERIAL
THE CLOTTING OF FIBRINOGEN .1. THE LIBERATION OF PEPTIDE MATERIAL
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DOI：
10.1016/0006-3002(55)90140-2
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发表时间：
1955-01-01
期刊：
影响因子：
--
通讯作者：
BETTELHEIM, FR
中科院分区：
文献类型：
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作者：
BAILEY, K;BETTELHEIM, FR
通过DNP技术估计表明牛纤维蛋白原的N末端残基是谷氨酸(1摩尔/265,000g)和酪氨酸(1摩尔/150,000g)。羧肽酶释放的氨基酸模式与纤维蛋白原和纤维蛋白相似，苯丙氨酸是每种情况下的主要成分。凝血时，肽物质从纤维蛋白原中释放出来。纤维蛋白原中存在但纤维蛋白中不存在的N端谷氨酸代表了断裂的链尖，而纤维蛋白的N端甘氨酸则代表了蛋白质分子主体上留下的“疤痕”。
Estimations by the DNP technique indicate that the N-terminal residues of bovine fibrinogen are glutamic acid (1 mole/ 265,000 g) and tyrosine (1 mole/150,000 g). The pattern of amino acids liberated by carboxypeptidase is similar for fibrinogen and fibrin, phenylalanine being the main component in each case. Peptide material is released from fibrinogen on clotting. The N-terminal glutamic acid which is present in fibrinogen but not in fibrin represents the tips of chains which are split off, while the N-terminal glycine of fibrin represents the "scars" left behind on the main body of the protein molecule.