Developmental changes in effective connectivity associated with relational reasoning
Developmental changes in effective connectivity associated with relational reasoning
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DOI：
10.1002/hbm.22400
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发表时间：
2014-07-01
影响因子：
4.8
通讯作者：
Dumontheil, Iroise
中科院分区：
文献类型：
--
作者：
Bazargani, Narges;Hillebrandt, Hauke;Dumontheil, Iroise
Rostrolateral prefrontal cortex（RLPFC）是额顶网络的一部分，涉及关系推理，即处理多种心理表征之间关系的心理过程。随着年龄的增长，RLPFC的功能和结构发生了变化，随着发展过程中关系整合的左RLPFC激活的特异性增加。在这里，我们使用动态因果模型（DCM），通过从青春期到成年期的过渡，在关系推理任务的有效连接的变化进行调查。我们检查了37名健康女性参与者（11-30岁）的功能磁共振成像数据进行关系推理范式。将关系整合与单一关系的操作进行比较，发现五个区域的激活：RLPFC、前额叶、背外侧PFC、顶叶下叶和内侧上级额回。我们使用了一种新的穷举搜索方法，并确定了一个完整的DCM模型，其中包括左半球五个集群之间的所有相互连接，作为最佳模型。与以前的静息状态功能磁共振成像结果一致，我们显示了不同的发展影响的强度，远距离额顶叶与额岛短距离固定连接。与关系整合相关的调节连接随着年龄的增长而增加。左侧RLPFC的灰质体积随年龄的增长而减少，部分原因是固定PFC连接的变化。最后，关系整合性能的改善与更大的调制和更弱的固定PFC连接。这种模式提供了进一步的证据，增加特异性的左PFC功能的关系整合相比，操纵单一的关系，并证明了有效的连接和性能之间的关联在发展过程中。《脑地图》35：3262-3276，2014年。(c)2013 Wiley Periodicals，Inc.
Rostrolateral prefrontal cortex (RLPFC) is part of a frontoparietal network of regions involved in relational reasoning, the mental process of working with relationships between multiple mental representations. RLPFC has shown functional and structural changes with age, with increasing specificity of left RLPFC activation for relational integration during development. Here, we used dynamic causal modeling (DCM) to investigate changes in effective connectivity during a relational reasoning task through the transition from adolescence into adulthood. We examined fMRI data of 37 healthy female participants (11-30 years old) performing a relational reasoning paradigm. Comparing relational integration to the manipulation of single relations revealed activation in five regions: the RLPFC, anterior insula, dorsolateral PFC, inferior parietal lobe, and medial superior frontal gyrus. We used a new exhaustive search approach and identified a full DCM model, which included all reciprocal connections between the five clusters in the left hemisphere, as the optimal model. In line with previous resting state fMRI results, we showed distinct developmental effects on the strength of long-range frontoparietal versus frontoinsular short-range fixed connections. The modulatory connections associated with relational integration increased with age. Gray matter volume in left RLPFC, which decreased with age, partly accounted for changes in fixed PFC connectivity. Finally, improvements in relational integration performance were associated with greater modulatory and weaker fixed PFC connectivity. This pattern provides further evidence of increasing specificity of left PFC function for relational integration compared to the manipulation of single relations, and demonstrates an association between effective connectivity and performance during development. Hum Brain Mapp 35:3262-3276, 2014. (c) 2013 Wiley Periodicals, Inc.