Cooperative nonlinearities in auditory cortical neurons
Cooperative nonlinearities in auditory cortical neurons
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DOI：
10.1016/j.neuron.2008.04.026
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发表时间：
2008-06-26
期刊：
影响因子：
16.2
通讯作者：
Schreiner, Christoph E.
中科院分区：
文献类型：
--
作者：
Atencio, Craig A.;Sharpee, Tatyana O.;Schreiner, Christoph E.
皮质接受场代表感觉神经元的信号偏好。人们认为接受场提供了脑皮质可以从中产生解释的感觉体验的代表。虽然必须确定神经元的接受场，但尚不清楚声学环境的哪些特征是由主要听觉皮层（AI）中的神经元特别代表的。我们通过找到尖峰触发的平均（STA）和刺激尺寸来最大程度地提高了响应和刺激之间的相互信息，从而表征了CAT AI光谱接收场（STA）。我们得出了一种非线性，将尖峰刺激投影到两个最大信息范围（MIDS）上。 STA与第一个MID高度相关。通常，第一个中间的非线性是不对称的，通常是单调的，而第二个非线性是对称的和非单调的。两个MIDS的关节非线性表明，大多数第一和第二中间都是协同的，因此应视为共同。非线性之间的差异表明了中MIDS在听觉处理中的不同作用。
Cortical receptive fields represent the signal preferences of sensory neurons. Receptive fields are thought to provide a representation of sensory experience from which the cerebral cortex may make interpretations. While it is essential to determine a neuron's receptive field, it remains unclear which features of the acoustic environment are specifically represented by neurons in the primary auditory cortex (AI). We characterized cat AI spectrotemporal receptive fields (STRFs) by finding both the spike-triggered average (STA) and stimulus dimensions that maximized the mutual information between response and stimulus. We derived a nonlinearity relating spiking to stimulus projection onto two maximally informative dimensions (MIDs). The STA was highly correlated with the first MID. Generally, the nonlinearity for the first MID was asymmetric and often monotonic in shape, while the second MID nonlinearity was symmetric and non-monotonic. The joint nonlinearity for both MIDs revealed that most first and second MIDs were synergistic and thus should be considered conjointly. The difference between the nonlinearities suggests different possible roles for the MIDs in auditory processing.