Constant composition dissolution kinetics studies of human dentin.
Constant composition dissolution kinetics studies of human dentin.
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人类牙本质的恒定成分溶解动力学研究。
DOI：
10.1177/00220345960750040401
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发表时间：
1996
影响因子：
7.6
通讯作者：
Nancollas,GH
中科院分区：
文献类型：
--
作者：
Paschalis,EP;Tan,J;Nancollas,GH
采用恒组成法（CC）研究了磷酸钙相对于羟基磷灰石（σHAP）的相对不饱和浓度（+0.8 ~ -2.8）、氯化钠或硝酸钾溶液中离子强度（0.05 ~ 0.30 mol/L-1）、pH值（4.00 ~ 5.50）和摩尔钙/磷酸盐比（0.05 ~ 11.1）对整个牙本质粉末溶出动力学的影响。结果表明，人牙本质表现为至少两种磷酸钙相的混合物，hap样磷酸钙和ocp样磷酸钙。即使在相对于HAP的过饱和溶液中也会发生显著的溶解，并且在反应溶液中受到离子强度、pH和摩尔钙/磷酸盐比的影响时，溶解速率对相对欠饱和表现出惊人的不敏感。虽然镁离子的存在延缓了溶解，但反应速率对磷酸钙的欠饱和表现出同样的不敏感。
The Constant Composition (CC) method has been used to study the dissolution kinetics of whole powdered human dentin as a function of calcium phosphate concentration at relative undersaturations with respect to hydroxyapatite (σHAP), ranging from +0.8 to -2.8, ionic strength from 0.05 to 0.30 mol/L-1 in sodium chloride or potassium nitrate, pH 4.00 to 5.50, and molar calcium/phosphate ratio in the reaction solutions from 0.05 to 11.1. The results suggest that human dentin behaves as a mixture of at least two calcium phosphate phases, HAP-like and octacalcium phosphate-like, OCP-like. Significant dissolution took place in solutions that were even supersaturated with respect to HAP, and the rates exhibited a striking insensitivity to relative undersaturation, while influenced by ionic strength, pH, and molar calcium/phosphate ratio in the reaction solutions. Although the dissolution was retarded in the presence of magnesium ion, the reaction rate showed the same insensitivity to undersaturation with respect to calcium phosphate.