The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
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DOI：
10.4049/jimmunol.173.9.5626
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发表时间：
2004-11-01
影响因子：
4.4
通讯作者：
Hunter, CA
中科院分区：
文献类型：
--
作者：
Artis, D;Villarino, A;Hunter, CA
虽然以前的研究已经研究了il -27/WSX-1相互作用在Th1反应调节中的作用，但对其在th2型反应调节中的作用知之甚少。本研究中提出的研究确定了il -27/WSX-1相互作用在2型反应的负调控中的直接作用，而不依赖于对1型细胞因子的影响。感染了胃肠道蠕虫Tichuris muris的WSX-1（-/-）小鼠由于Th2细胞因子的产生增加，表现出肠道寄生虫的加速排出和过度的杯状细胞增生和肥大细胞增生。在缺乏WSX-1的情况下，肥大细胞活性增强与野生型肥大细胞表达该受体的能力是一致的。此外，IL-27直接抑制CD4(+) T细胞增殖和Th2细胞因子的产生。总之，这些研究确定了il -27/WSX-1在限制黏膜2型免疫的先天和适应性成分中的新作用
Although previous studies have investigated the role of IIL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IIL-27/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1(-/-) mice infected with the gastrointestinal helminth Tichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosks in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, IL-27 directly suppressed CD4(+) T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IIL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal