Comparison of spatial integration and surround suppression characteristics in spiking activity and the local field potential in macaque V1
Comparison of spatial integration and surround suppression characteristics in spiking activity and the local field potential in macaque V1
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DOI：
10.1111/j.1460-9568.2008.06358.x
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发表时间：
2008-08-01
影响因子：
3.4
通讯作者：
Thiele, A.
中科院分区：
文献类型：
--
作者：
Gieselmann, M. A.;Thiele, A.
初级视皮层中的神经元表现出有据可查的中心-周围感受野组织，其中中心由兴奋性影响主导，而周围通常由抑制性影响主导。这些效应在很大程度上是通过测量神经元的输出，即它们的尖峰活动来确定的。兴奋和抑制是如何反映在局部场电位（LFP）的了解很少。由于这可以承担对人类fMRI BOLD数据的解释和我们对局部场电位振荡机制的理解，我们测量了空间整合和中心-环绕特性，在清醒的固定猕猴的V1的单和多单元记录，并比较这些频谱功率在不同频段的同时记录的LFPs。我们通过确定尖峰活动以及LFP的不同频带中的总和和抑制区域的大小来量化中心-周围组织，主要关注伽马频带。光栅延伸超出总和面积通常抑制尖峰活动，而LFP伽马波段的活动单调增加的所有光栅尺寸。这种增加是最大的刺激侵犯了近经典的感受野周围，抑制开始占主导地位的尖峰活动。因此，抑制在初级皮层的影响，可以推断从尖峰活动，但他们似乎也影响特定功能的γ-波段LFP活动。
Neurons in primary visual cortex exhibit well documented centre-surround receptive field organization, whereby the centre is dominated by excitatory influences and the surround is generally dominated by inhibitory influences. These effects have largely been established by measuring the output of neurons, i.e. their spiking activity. How excitation and inhibition are reflected in the local field potential (LFP) is little understood. As this can bear on the interpretation of human fMRI BOLD data and on our understanding of the mechanisms of local field potential oscillations, we measured spatial integration and centre-surround properties in single- and multiunit recordings of V1 in the awake fixating macaque monkey, and compared these to spectral power in different frequency bands of simultaneously recorded LFPs. We quantified centre-surround organization by determining the size of the summation and suppression area in spiking activity as well as in different frequency bands of the LFP, with the main focus on the gamma band. Gratings extending beyond the summation area usually inhibited spiking activity while the LFP gamma-band activity increased monotonically for all grating sizes. This increase was maximal for stimuli infringing upon the near classical receptive field surround, where suppression started to dominate spiking activity. Thus, suppressive influences in primary cortex can be inferred from spiking activity, but they also seem to affect specific features of gamma-band LFP activity.