The effect of regulatory advisories on maternal antidepressant prescribing, 1995-2007: an interrupted time series study of 228,876 pregnancies.
The effect of regulatory advisories on maternal antidepressant prescribing, 1995-2007: an interrupted time series study of 228,876 pregnancies.
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DOI：
10.1007/s00737-013-0383-6
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发表时间：
2014-02
影响因子：
4.5
通讯作者：
Wu, Pingsheng
中科院分区：
文献类型：
--
作者：
Bobo, William V.;Epstein, Richard A., Jr.;Hayes, Rachel M.;Shelton, Richard C.;Hartert, Tina V.;Mitchel, Ed;Horner, Jeff;Wu, Pingsheng
关键词：
To assess whether antidepressant prescribing during pregnancy decreased following release of U.S. and Canadian public health advisory warnings about the risk of perinatal complications with antidepressants. We analyzed data from 228,876 singleton pregnancies among women (aged 15–44 years) continuously enrolled in Tennessee Medicaid with full pharmacy benefits (1995–2007). Antidepressant prescribing was determined through outpatient pharmacy dispensing files. Information on sociodemographic and clinical factors was obtained from enrollment files and linked birth certificates. An interrupted time-series design with segmented regression analysis was used to quantify the impact of the advisory warnings (2002–2005). Antidepressant prescribing rates increased steadily from 1995–2001, followed by sharper increases from 2002–late 2004. Overall antidepressant prescribing prevalence was 34.51 prescriptions (95% CI 33.37–35.65) per 1,000 women in January 2002, and increased at a rate of 0.46 (95% CI 0.41–0.52) prescriptions per 1,000 women per month until the end of the pre-warning period (May 2004). During the post-warning period (October 2004 – June 2005), antidepressant prescribing decreased by 1.48 (95% CI 1.62-1.35) prescriptions per 1,000 women per month. These trends were observed for both SSRI and non-SSRI antidepressants, although SSRI prescribing decreased at a greater rate. Antidepressant prescribing to pregnant women in Tennessee Medicaid increased from 1995–late 2004. U.S. and Canadian public health advisories about antidepressant-associated perinatal complications were associated with steady decreases in antidepressant prescribing from late 2004 until the end of the study period, suggesting that the advisory warnings were impactful on antidepressant prescribing in pregnancy.
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影响因子：
9.8
作者：
Cooper, William O.;Willy, Mary E.;Ray, Wayne A.
通讯作者：
Ray, Wayne A.
影响因子：
120.7
作者：
Cohen, LS;Altshuler, LL;Stowe, ZN
通讯作者：
Stowe, ZN
DOI：
10.4088/jcp.9058se1c.04gry
发表时间：
2010-01-01
期刊：
The Journal of clinical psychiatry
影响因子：
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作者：
Davidson, Jonathan R T
通讯作者：
Davidson, Jonathan R T
影响因子：
3.4
作者：
Bakker, Marian K.;Kolling, Pieternel;van den Berg, Lolkje T. W. de Jong
通讯作者：
van den Berg, Lolkje T. W. de Jong
影响因子：
4.5
作者：
Bilszta, Justin L. C.;Tsuchiya, Shauna;Einarson, Adrienne
通讯作者：
Einarson, Adrienne