BIOCHEMICAL-STUDIES ON REPAIR CARTILAGE RESURFACING EXPERIMENTAL DEFECTS IN THE RABBIT KNEE
BIOCHEMICAL-STUDIES ON REPAIR CARTILAGE RESURFACING EXPERIMENTAL DEFECTS IN THE RABBIT KNEE
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DOI：
10.2106/00004623-198062010-00012
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发表时间：
1980-01-01
影响因子：
5.3
通讯作者：
GLIMCHER, MJ
中科院分区：
文献类型：
--
作者：
FURUKAWA, T;EYRE, DR;GLIMCHER, MJ
穿透关节软骨至骨的伤口愈合时，软骨被描述为纤维状或透明状。在兔中诱导这种修复软骨，用于与正常关节软骨进行生物化学比较。3 wk后修复组织中主要胶原为I型胶原。到6-8周，II型已成为主要的，并继续丰富到1年，但I型仍然坚持作为一个重要组成部分的修复组织，即使在1年后，所以修复软骨从来没有完全类似于正常的关节软骨。从放射化学分析，II型被确定为3-4周后由修复组织合成的主要胶原。6个月后，与对照软骨相比，修复软骨含有更多的胶原蛋白和更少的己糖胺，这表明经常形成的纤维质地是由于蛋白聚糖的损失而不是胶原蛋白类型的改变。能够诱导真正的关节软骨分化，以重建退化的人类关节的程序将是非常宝贵的。经常尝试手术方法，例如钻穿至软骨下骨。形成的软骨是否是真正的关节软骨，纤维软骨，尚不清楚。并将其与正常兔关节软骨的特性进行了比较。
Wounds penetrating articular cartilage to bone heal with cartilage described variably as either fibrous or hyaline. Such repair cartilage was induced in the rabbit for biochemical comparison with normal articular cartilage. The main collagen in the repair tissue after 3 wk was type I. By 6-8 wk, type II had become predominant and continued to be enriched up to 1 yr; but type I still persisted as a significant constituent of the repair tissue even after 1 yr, so the repair cartilage never fully resembled normal articular cartilage. From radiochemical analysis, type II was determined to be the major collagen synthesized by the repair tissue after 3-4 wk. After 6 mo., the repair cartilage contained more collagen and less hexosamine than control cartilage, suggesting that the fibrous texture that often developed was due to a loss of proteoglycans rather than to a change in the type of collagen. Procedures capable of inducing the differentiation of authentic articular cartilage to resurface degenerated human joints would be invaluable. Surgical methods, such as drilling through to subchondral bone, are often attempted. Whether the cartilage that forms is true articular cartilage or, e.g., fibrocartilage, is not yet known. The properties of such repair cartilage with those of normal articular cartilage were compared in the rabbit.