Cargo transport: molecular motors navigate a complex cytoskeleton
Cargo transport: molecular motors navigate a complex cytoskeleton
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DOI：
10.1016/j.ceb.2007.11.006
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发表时间：
2008-02-01
影响因子：
7.5
通讯作者：
Warshaw, David M.
中科院分区：
文献类型：
--
作者：
Ross, Jennifer L.;Ali, M. Yusuf;Warshaw, David M.
细胞内的货物运输需要基于微管的马达、驱动蛋白和细胞质动力蛋白以及基于肌动蛋白的肌球蛋白马达来操纵通过由构成细胞骨架的丝状网络所提出的挑战。最近的体外单分子生物物理学研究已经开始探索这一过程，通过表征当这些微小的分子马达发生在两个细胞骨架丝之间的交叉点时发生的事情。这些研究与体内工作相结合，定义了分子马达在丝状轨道之间移动时交换货物并将其从细胞中心运送到外周并再次返回时将其运送到目的地的机制。
Intracellular cargo transport requires microtubule-based motors, kinesin and cytoplasmic dynein, and the actin-based myosin motors to maneuver through the challenges presented by the filamentous meshwork that comprises the cytoskeleton. Recent in vitro single molecule biophysical studies have begun to explore this process by characterizing what occurs as these tiny molecular motors happen upon an intersection between two cytoskeletal filaments. These studies, in combination with in vivo work, define the mechanism by which molecular motors exchange cargo while traveling between filamentous tracks and deliver it to its destination when going from the cell center to the periphery and back again.