Long COVID (post-COVID-19 condition) in children: a modified Delphi process.
Long COVID (post-COVID-19 condition) in children: a modified Delphi process.
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DOI：
10.1136/archdischild-2021-323624
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发表时间：
2022-07
影响因子：
5.2
通讯作者：
Shafran R
中科院分区：
文献类型：
--
作者：
Stephenson T;Allin B;Nugawela MD;Rojas N;Dalrymple E;Pinto Pereira S;Soni M;Knight M;Cheung EY;Heyman I;CLoCk Consortium;Shafran R
这项研究的目的是给儿童和年轻人“新冠肺炎后慢性冠脉疾病”的研究定义(CYP)，以便在研究研究之间进行比较。使用了三个阶段的在线德尔福进程，然后举行了协商一致的会议。参与者在每个阶段都有49条陈述，并根据它们在CYP中长期COVID的研究定义中的重要性对它们进行了从1到9的评分。举行协商一致会议是为了实现利益攸关方群体的代表性。患者和公众参与(PPI)研究咨询小组的与会者审查了在协商一致会议上达成的声明。这项研究是通过在线调查和虚拟共识会议远程进行的。120名具有相关专业知识的人根据他们的专业领域被分为三个小组：服务提供、研究(或研究和服务提供的组合)和生活体验。PPI研究顾问组由11-17岁的CYP组成。协商一致意见是使用现有准则确定的。如果在两个或多个小组中达成了协商一致意见，或者在一个小组和两个小组之间达成了共识，则在协商一致会议上对这些发言进行讨论和表决。在协商一致会议上提出了10项声明供讨论，其中5项声明达到阈值，将纳入青年团关于长期COVID的研究定义。这项研究的定义与世界卫生组织的临床病例定义一致，建议如下：新冠肺炎后疾病发生在有确诊的SARS-CoV-2感染史的年轻人中，在首次检测后至少有一种持续12周的身体症状，而这种症状无法用替代诊断来解释。这些症状对日常功能有影响，可能在感染COVID后继续或发展，并可能随着时间的推移波动或复发。本定义中所指的新冠肺炎阳性试验可以是侧向流动抗原试验、聚合酶链式反应试验或抗体试验。这是CYP对长COVID(新冠肺炎后条件)的第一个研究定义，是对世界卫生组织提出的成人临床病例定义的补充。怎样才能理解儿童长期卧床不起呢？一种方法是就研究定义达成共识。作者描述了一种改进的德尔福方法，其中包括具有生活经验、研究和服务交付的人。
The aim of this study was to derive a research definition for ‘Long COVID (post-COVID-19 condition)’ in children and young people (CYP) to allow comparisons between research studies. A three-phase online Delphi process was used, followed by a consensus meeting. Participants were presented with 49 statements in each phase and scored them from 1 to 9 based on how important they were for inclusion in the research definition of Long COVID in CYP. The consensus meeting was held to achieve representation across the stakeholder groups. Statements agreed at the consensus meeting were reviewed by participants in the Patient and Public Involvement (PPI) Research Advisory Group. The study was conducted remotely using online surveys and a virtual consensus meeting. 120 people with relevant expertise were divided into three panels according to their area of expertise: Service Delivery, Research (or combination of research and service delivery) and Lived Experience. The PPI Research Advisory group consisted of CYP aged 11–17 years. Consensus was defined using existing guidelines. If consensus was achieved in two or more panels or was on the border between one and two panels, those statements were discussed and voted on at the consensus meeting. Ten statements were taken forward for discussion in the consensus meeting and five statements met threshold to be included in the research definition of Long COVID among CYP. The research definition, aligned to the clinical case definition of the WHO, is proposed as follows: Post-COVID-19 condition occurs in young people with a history of confirmed SARS-CoV-2 infection, with at least one persisting physical symptom for a minimum duration of 12 weeks after initial testing that cannot be explained by an alternative diagnosis. The symptoms have an impact on everyday functioning, may continue or develop after COVID infection, and may fluctuate or relapse over time. The positive COVID-19 test referred to in this definition can be a lateral flow antigen test, a PCR test or an antibody test. This is the first research definition of Long COVID (post-COVID-19 condition) in CYP and complements the clinical case definition in adults proposed by the WHO. How might one understand long covid in children? One way is to arrive at a consensus on a research definition. The authors describe a modified Delphi approach, which included people with lived experience, research and service delivery.
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影响因子：
8
作者：
Kelly, Lauren E.;Shan, Flora;Offringa, Martin
通讯作者：
Offringa, Martin
影响因子：
3.6
作者：
Bierle DM;Aakre CA;Grach SL;Salonen BR;Croghan IT;Hurt RT;Ganesh R
通讯作者：
Ganesh R
DOI：
10.1016/s2352-4642(20)30304-7
发表时间：
2021-03
期刊：
The Lancet. Child & adolescent health
影响因子：
--
作者：
Harwood R;Allin B;Jones CE;Whittaker E;Ramnarayan P;Ramanan AV;Kaleem M;Tulloh R;Peters MJ;Almond S;Davis PJ;Levin M;Tometzki A;Faust SN;Knight M;Kenny S;PIMS-TS National Consensus Management Study Group
通讯作者：
PIMS-TS National Consensus Management Study Group
影响因子：
5.9
作者：
Tejwani, Vickram;Chang, Hsing-Yuan;Moloney, Rachael M.
通讯作者：
Moloney, Rachael M.
影响因子：
5.2
作者：
Allin BSR;Bradnock T;Kenny S;Kurinczuk JJ;Walker G;Knight M;NETS1HD Collaboration
通讯作者：
NETS1HD Collaboration