Inhibition of human brain tumor cell growth by a receptor-operated Ca2+ channel blocker.
Inhibition of human brain tumor cell growth by a receptor-operated Ca2+ channel blocker.
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DOI：
10.1016/0304-3835(93)90014-z
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发表时间：
1993-08
期刊：
影响因子：
9.7
通讯作者：
Y. Lee;M. Sayeed;R. Wurster
中科院分区：
文献类型：
--
作者：
Y. Lee;M. Sayeed;R. Wurster
SK&F 96365, a reported receptor-operated Ca2+channel blocker, inhibited the growth of U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cell lines in a dose-dependent manner. Carbachol and serum which act as growth factors for these cells induced a rapid, transient increase of intracellular Ca2+concentration without a sustained increase. SK&F 96365 also exerted a significant inhibition of carbachol or serum-induced intracellular Ca2+mobilization. These results suggest that SK&F 96365 is a potent inhibitor of brain tumor cell growth and that its effect may be mediated by the inhibition of agonist-induced intracellular Ca2+mobilization.
