SIMULTANEOUS LTP OF NON-NMDA-RECEPTER-MEDIATED AND LTD OF NMDA-RECEPTER-MEDIATED RESPONSES IN THE NUCLEUS-ACCUMBENS
SIMULTANEOUS LTP OF NON-NMDA-RECEPTER-MEDIATED AND LTD OF NMDA-RECEPTER-MEDIATED RESPONSES IN THE NUCLEUS-ACCUMBENS
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DOI：
10.1038/368242a0
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发表时间：
1994-03-17
期刊：
影响因子：
64.8
通讯作者：
MALENKA, RC
中科院分区：
文献类型：
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作者：
KOMBIAN, SB;MALENKA, RC
伏隔核（NA）是纹状体的腹侧延伸，在几种复杂的行为模式中起作用(1)，也是可卡因等滥用药物的主要作用部位（1-3）。固有NA细胞主要是静止的（4,5），它们的活动依赖于皮层和皮层下边缘传入的兴奋性输入（6,7）。在这里，我们研究了边缘皮层传入事件和NA核心区域细胞之间突触的突触可塑性机制（8-10）。诱导非nmda （n-甲基- d -天冬氨酸）受体介导的反应的Ca2+依赖性长期增强（LTP）的操作也同时产生nmda受体介导的反应的长期抑制（LTD）。这些结果表明，在单个细胞中，突触后Ca2+浓度的相同变化可以对非nmda和nmda受体介导的突触反应产生相反的影响。这在NA中可能特别重要，其中NMDA受体对于介导药物滥用的行为行为至关重要（11-13）。
THE nucleus accumbens (NA), a ventral extension of the striatum, plays a role in several complex behaviour patterns(1) and also is a major site of action of drugs of abuse such as cocaine(1-3). Intrinsic NA cells are predominantly quiescent(4,5) and their activity depends on excitatory input from cortical and subcortical limbic afferents(6,7). Here we examine the mechanisms of synaptic plasticity at the synapse between prelimbic cortical afferents and cells in the core region of the NA(8-10). Manipulations that induce a Ca2+- dependent long-term potentiation (LTP) of non-NMDA (N-methyl-D-aspartate)-receptor-mediated responses also produce a simultaneous long-term depression (LTD) of NMDA-receptor-mediated responses. These results indicate that in a single cell the same change in postsynaptic Ca2+ concentration can have opposite effects on non-NMDA- and NMDA-receptor-mediated synaptic responses. This may be particularly important in the NA, where NMDA receptors are critical for mediating the behavioural actions of drugs of abuse(11-13).