Increased ventricular repolarization heterogeneity in patients with ventricular arrhythmia vulnerability and cardiomyopathy: a human in vivo study
Increased ventricular repolarization heterogeneity in patients with ventricular arrhythmia vulnerability and cardiomyopathy: a human in vivo study
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DOI：
10.1152/ajpheart.00648.2005
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发表时间：
2006-01-01
影响因子：
4.8
通讯作者：
Picton, P
中科院分区：
文献类型：
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作者：
Chauhan, VS;Downar, E;Picton, P
在心肌病动物模型中，复极不均一性的增加为折返性室性心律失常提供了底物。我们假设有心肌病和室性心律失常易感性(诱发性室性心动过速或正微伏T波交替，VT/TWA)的患者与没有室性心律失常易感性的相似患者(无VT/TWA)相比，心室复极异质性也更大。应用经静脉26电极右室心内膜和左心外膜导管测量了12例室速和10例非室速患者心内膜和心外膜复极的异质性。从单极心电图测量局部激活时间(AT)、激活-恢复间期(ARI)和复极时间(RT)。心内膜RT沿心尖基底室的离散度较大(P
Increased repolarization heterogeneity can provide the substrate for reentrant ventricular arrhythmias in animal models of cardiomyopathy. We hypothesized that ventricular repolarization heterogeneity is also greater in patients with cardiomyopathy and ventricular arrhythmia vulnerability (inducible ventricular tachycardia or positive microvolt T wave alternans, VT/TWA) compared with a similar patient population without ventricular arrhythmia vulnerability (no VT/TWA). Endocardial and epicardial repolarization heterogeneity was measured in patients with (n = 12) and without (n = 10) VT/TWA by using transvenous 26-electrode catheters placed along the anteroseptal right ventricular endocardium and left ventricular epicardium. Local activation times (AT), activation- recovery intervals (ARI), and repolarization times (RT) were measured from unipolar electrograms. Endocardial RT dispersion along the apicobasal ventricle was greater (P