Protein Targeting during Bacillus subtilis Sporulation
Protein Targeting during Bacillus subtilis Sporulation
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DOI：
10.1128/microbiolspec.tbs-0006-2012
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发表时间：
2014-02-01
影响因子：
3.7
通讯作者：
Dworkin, Jonathan
中科院分区：
文献类型：
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作者：
Dworkin, Jonathan
革兰氏阳性菌枯草芽孢杆菌在营养限制条件下启动内生孢子的形成。孢子经历的形态分化起始于靠近细胞一极的不对称隔膜的形成，形成较小的隔室，即前孢子，和较大的隔室，即母细胞。这一过程继续与复杂的形态发生的孢子所管辖的一系列错综复杂的相互作用之间的前孢子和母细胞蛋白质的内部和外部前孢子膜。鉴于这些相互作用发生在细胞中的特定位置，一个关键问题是参与这些过程的蛋白质如何正确靶向，我们讨论了确定这种靶向机制的最新进展。
The Gram-positive bacteriumBacillus subtilis initiates the formation of an endospore in response to conditions of nutrient limitation. The morphological differentiation that spores undergo initiates with the formation of an asymmetric septum near to one pole of the cell, forming a smaller compartment, the forespore, and a larger compartment, the mother cell. This process continues with the complex morphogenesis of the spore as governed by an intricate series of interactions between forespore and mother cell proteins across the inner and outer forespore membranes. Given that these interactions occur at a particular place in the cell, a critical question is how the proteins involved in these processes get properly targeted, and we discuss recent progress in identifying mechanisms responsible for this targeting.