DESIPRAMINE IN SMALL DOSES INDUCES ANTINOCICEPTION IN THE INCREASING TEMPERATURE HOT-PLATE TEST, BUT NOT IN THE TAIL-FLICK TEST
DESIPRAMINE IN SMALL DOSES INDUCES ANTINOCICEPTION IN THE INCREASING TEMPERATURE HOT-PLATE TEST, BUT NOT IN THE TAIL-FLICK TEST
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DOI：
10.1016/0028-3908(89)90207-4
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发表时间：
1989-11-01
影响因子：
4.7
通讯作者：
HOLE, K
中科院分区：
文献类型：
--
作者：
LUND, A;TJOLSEN, A;HOLE, K
报道的三环类抗抑郁药的抗伤害作用的数据是相互矛盾的。在这项研究中，急性腹膜内（i. p.）使用同时测量尾部皮肤温度的甩尾试验和升温热板试验，研究了在大鼠中给予地昔帕明（2和5 mg/kg）。如前所述，在这项研究中还发现了甩尾潜伏期和尾部皮肤温度之间的恒定负相关。不同的环境温度影响甩尾试验的结果。在24 - 25 ℃的环境温度下，在甩尾试验中，地昔帕明引起明显的抗伤害感受作用，这是由尾部皮肤温度的相对下降引起的。在21 - 22度。C，地昔帕明给药后，甩尾潜伏期无变化。然而，在升温热板试验中，地昔帕明的镇痛作用呈剂量依赖性。然而，在升温热板试验中，在两种环境温度下均观察到地昔帕明的剂量依赖性镇痛作用。环境温度的适度差异对甩尾试验结果的强烈影响可以解释文献中报道的一些相互矛盾的结果。无论何时使用该试验，都应记录尾部的温度，并在评估数据时加以考虑。
The data reported for the antinociceptive effect of tricyclic antidepressants are conflicting. In this investigation, the effect of acute intraperitoneal (i.p.) adminsitration of desipramine (2 and 5 mg/kg) was studied in rats, using the tail-flick test with simultaneous measurement of tail-skin temperature, and the increasing temperature hot-plate test. A constant negative correlation between tail-flick latency and tail-skin temperature, as described earlier, was also found in this study. Different ambient temperatures influenced the results of the tail-flick test. At an ambient temperature of 24-25.degree. C, desipramine gave rise to an apparent antinociception in the tail-flick test, which was found to be caused by a relative fall in tail-skin temperature. At 21-22.degree. C, no change in tail-flick latency was found after the administration of desipramine. In the increasing temperature hot-plate test, however, a dose-dependent antinociceptive effect of desipramine. In the increasing temperature hot-plate test, however, a dose-dependent antinociceptive effect of desipramine was observed at both ambient temperatures. The strong influence of moderate differences in ambient temperature on the results of the tail-flick test may explain some of the conflicting results reported in the literature. Whenever this test is used, the temperature of the tail should be recorded and taken into account in the evaluation of the data.