Premixed calcium-phosphate cement pastes
Premixed calcium-phosphate cement pastes
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DOI：
10.1002/jbm.b.10065
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发表时间：
2003-11-15
影响因子：
3.4
通讯作者：
Sugawara, A
中科院分区：
文献类型：
--
作者：
Takagi, S;Chow, LC;Sugawara, A
含Ca-4（PO 4）（2）O和CaHPO 4的自硬化磷酸钙骨水泥（CPC）在临床研究中已被证明可有效修复骨缺损。这种和其他几种类似的CPC在使用磷酸盐溶液作为液体的情况下在10分钟内硬化，并形成作为产物的羟基磷灰石（HA）。本研究调查了无水，含甘油的CPC糊剂的性质，这些糊剂在包装中是稳定的，并且仅在被递送到发生甘油-组织液交换的缺损部位后才会硬化。通过将含有甘油和不同量的羟丙基甲基纤维素/Na 2 HPO 4的骨水泥液体与含有（1）Ca-4（PO 4）（2）O和CaHPO 4、（2）α-Ca-3（PO 4）（2）和CaCO 3或（3）CaHPO 4和Ca（OH）（2）的CPC粉末组合来制备预混CPC糊剂。在体外模型中硬化的样品上测量硬化时间和1-d和7-d径向拉伸强度，该模型允许在37 ℃下通过烧结玻璃载玻片交换甘油和生理类溶液（PLS）。所有糊剂都具有优异的耐冲刷性;它们在浸入PLS中时保持完整并硬化，并形成HA产物。Newman-Keulls多重比较试验表明，Na_2HPO_4用量对强度和硬化时间的影响显著（P < 0.05），而羟丙基甲基纤维素（HMC）用量对强度和硬化时间的影响不显著（P> 0.05）。虽然预混CPC通常具有较长的硬化时间和较低的强度，但这些糊剂在硬化之前具有优异的耐冲刷性，并且可以在良好控制的条件下预先制备。(C)2003 Wiley Periodicals，Inc.
A self-hardening calcium-phosphate cement (CPC) containing Ca-4(PO4)(2)O and CaHPO4 has been shown in clinical studies to be efficacious for repairing bone defects. This and several other similar CPCs harden in 10 min with the use of a phosphate solution as the liquid and form hydroxyapatite (HA) as the product. The present study investigated the properties of water-free, glycerol-containing CPC pastes that are stable in the package and would harden only after being delivered to a defect site where glycerol-tissue fluids exchange occurs. Premixed CPC pastes were prepared by combining cement liquids containing glycerol and various amounts of hydroxypropyl methylcellulose/Na2HPO4, with CPC powders that contained (1) Ca-4(PO4)(2)O and CaHPO4, (2) alpha-Ca-3(PO4)(2) and CaCO3, or (3) CaHPO4 and Ca(OH)(2). The hardening times and 1-d and 7-d diametral tensile strengths were measured on samples that hardened in an in vitro model that allowed exchange of glycerol and physiologic-like solution (PLS) through fritted glass slides at 37 degreesC. All pastes had excellent washout resistance; they remained intact and hardened while immersed in PLS and formed HA as products. Newman-Keulls multiple comparison tests indicated that the Na2HPO4 amount, not the hydroxypropyl methyllcellulose (HMC) amount, significantly (P < 0.05) affected the strength and hardening time. Although the premixed CPCs generally have longer hardening times and lower strengths, these pastes have excellent washout resistance before hardening and can be prepared in advance under well-controlled conditions. (C) 2003 Wiley Periodicals, Inc.