Reflections on ten years of history of, and future prospects for, GW182 and GW/P body research.
Reflections on ten years of history of, and future prospects for, GW182 and GW/P body research.
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GW182和GW/P体研究十年历程的反思和未来展望。
DOI：
10.1007/978-1-4614-5107-5_15
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发表时间：
2013
影响因子：
--
通讯作者：
Fritzler,MarvinJ
中科院分区：
文献类型：
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作者：
Chan,EdwardKL;Yao,Bing;Fritzler,MarvinJ
关于全身性风湿性疾病中的人自身抗体的文献已经清楚地阐明了主要的自身免疫靶点，其中许多是核酸-蛋白质大分子复合物或亚细胞颗粒（Tan et al. 1988）。其中有充分证据的例子包括核糖核蛋白Sm/RNP复合物，由富含U的小核核糖核蛋白（UsnRNP）的关键组分组成，这些组分对mRNA剪接过程至关重要，以及由DNA、组蛋白和高迁移率族蛋白组成的染色质亚基。尽管关于为什么这些是B细胞应答的靶点仍然存在未解答的问题，但目前的想法是这些核酸-蛋白质复合物是系统性自身免疫性疾病中的首选靶点自身抗原，因为它们与Toll样受体（TLR）相互作用。TLR 3、7和9主要位于内体中，负责感应内源性RNA和DNA配体（Kawai和Akira 2009）。因此，内源性核酸-蛋白质复合物具有更高的刺激B细胞自身免疫应答的倾向。
The literature on human autoantibodies in systemic rheumatic diseases has clearly elucidated major autoimmune targets, many of which are nucleic acid-protein macromolecular complexes or subcellular particles (Tan et al. 1988). Well-documented examples of these include the ribonucleoprotein Sm/RNP complex comprised of key components of U-rich small nuclear ribonucleoproteins (UsnRNPs) that are critical for processes in mRNA splicing, and chromatin subunits composed of DNA, histones and high mobility group proteins. Although there are still unanswered questions about why these are the targets of the B-cell response, the current thinking is that these nucleic acid-protein complexes are preferred target autoantigens in systemic autoimmune diseases because of their interactions with toll-like receptors (TLR). TLR3, 7, and 9 are primarily located in the endosomes and are responsible for sensing of endogenous RNA and DNA ligands (Kawai and Akira 2009). Thus, endogenous nucleic acids-protein complexes have a higher tendency to stimulate a B-cell autoimmune response.