Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity
Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity
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促胰液素受体缺陷的小鼠在轮跑活动中表现出昼夜节律改变
DOI：
10.1016/j.neulet.2020.134814
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发表时间：
2020
影响因子：
2.5
通讯作者：
Nakamura Takahiro J.
中科院分区：
文献类型：
--
作者：
Sugiyama Mizuki;Nishijima Ichiko;Miyazaki Shota;Nakamura Takahiro J.
在哺乳动物中，行为和生理活动的时间由下丘脑的视交叉上核（SCN）控制。顺便提一下，分泌素是一种促进消化活动和调节水分再吸收的肽激素。在最近的研究中，外源性分泌素被报道诱导下丘脑视上核分泌催产素并调节社会行为。这些结果表明分泌素参与控制社会行为的神经网络，在中枢神经系统中起着重要作用。在本研究中，我们研究了分泌素对昼夜节律的影响，通过评估分泌素受体缺陷（Sctr−/−）小鼠在轮跑行为中的昼夜节律。雄性成年野生型（WT）小鼠和sctr -/-小鼠分别饲养在装有轮子的不同笼子中。在正常光照-黑暗（LD）周期（12:12 h）和持续黑暗（DD）中监测每分钟的车轮运行活动。WT和sctr - / -小鼠在自由奔跑期观察到显著差异。然而，在LD和DD条件下，WT和sctr - / -小鼠之间的每日滚轮转数没有显著差异。此外，在DD条件下，sctr−/−小鼠的日常活动期与休息期之比（α/ρ）显著小于WT小鼠。分泌素受体在SCN细胞中表达。这些发现表明分泌素受体参与了SCN的中央生物钟和一般的昼夜节律系统。
In mammals, the timing of behavior and physiological activity is controlled by the suprachiasmatic nucleus (SCN) in the hypothalamus. Incidentally, secretin is a peptide hormone that promotes digestive activities and regulates water reabsorption. In recent studies, exogenous administration of secretin has been reported to induce secretion of oxytocin in the supraoptic nucleus of the hypothalamus and modulate social behavior. These results indicate that secretin is involved in the neural network that controls social behavior and plays important roles in the central nervous system. In the present study, we investigated the effects of secretin on circadian rhythms, by assessing circadian rhythms during wheel-running behavior in secretin receptor-deficient (Sctr−/−) mice. Male adult wild-type (WT) andSctr-/-mice were housed in separate cages containing a wheel. Every minute of the wheel-running activity was monitored during the normal light-dark (LD) cycle (12:12 h) and in constant darkness (DD). Significant differences were observed in the free-running period between the WT andSctr−/−mice. However, no significant differences were observed in the daily wheel-running revolutions between WT andSctr−/−mice, in the LD and DD conditions. Moreover, the ratio of the daily activity phase to the rest phase (α/ρ) was significantly smaller inSctr−/−than that in WT mice in the DD condition. Secretin receptors were expressed in the SCN cells. These findings suggest that secretin receptors are involved in the central circadian clock in the SCN and the circadian system in general.
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DOI：
10.1152/ajpregu.90463.2008
发表时间：
2009-03-01
影响因子：
2.8
作者：
Li, Jia-Da;Burton, Katherine J.;Zhou, Qun-Yong
通讯作者：
Zhou, Qun-Yong
影响因子：
17.7
作者：
Bolbecker, Amanda R.;Hetrick, William P.;Shekhar, Anantha S.
通讯作者：
Shekhar, Anantha S.
影响因子：
18.2
作者：
Welsh DK;Takahashi JS;Kay SA
通讯作者：
Kay SA
介导大鼠前胃松弛的促胰液素受体。
DOI：
10.1152/ajpgi.1993.264.5.g863
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
T. Steiner;A. Mangel;D. C. Mcvey;S. Vigna
通讯作者：
S. Vigna
大鼠促胰液素受体高亲和力结合血管活性肠多肽的分子基础和物种特异性。
DOI：
--
发表时间：
1996
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Holtmann,MH;Hadac,EM;Ulrich,CD;Miller,LJ
通讯作者：
Miller,LJ