Impact of coronary bifurcated vessels flow-diameter scaling laws on fractional flow reserve based on computed tomography images (FFRCT).
Impact of coronary bifurcated vessels flow-diameter scaling laws on fractional flow reserve based on computed tomography images (FFRCT).
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DOI：
10.3934/mbe.2022145
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发表时间：
2022-01
期刊：
影响因子：
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通讯作者：
Na Li;Bao Li;Yili Feng;Junling Ma;Liyuan Zhang;Jian Liu;Youjun Liu
中科院分区：
文献类型：
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作者：
Na Li;Bao Li;Yili Feng;Junling Ma;Liyuan Zhang;Jian Liu;Youjun Liu
目的探讨MATHROM{Q}、MAXTHM{Q}、MATHROM{α}、MATHROM{D}、MATHROM{Q}、MATHROM{Aα、MATHROM{D}的血流直径标度规律对基于CTA图像的分数血流储备数值模拟的影响，并寻找最佳指数。方法1)根据纳入标准筛选26例冠心病患者；2)计算3、2.7和7/3次方的微循环阻力(Rm)，分别记为3Rm、2.7Rm和7/3Rm；3)以3Rm、2.7Rm和7/3Rm为出口边界条件模拟FFRCT，分别引用3FRRCT、2.7FRCT和7/3FRCT；4)分析三种FFRCT与FFR的相关性和诊断性能。结果3Rm、2.7Rm、7/3Rm与FFR的p值分别为0.004、0.005、0.010，7/3FRCT与FFR的相关系数(r=0.96)好于3FRCT(0.95)、2.7FRCT(0.95)，7/3FRCT与FFR的95%LOA(-0.08~0.11)小于3FRCT(-0.10~0.12)、2.7FRCT(-0.09~0.11)；7/3FRCT的AUC[0.962(0.805~0.999)，96.15%]与2.7FRCT[0.962(0.805~0.999)，96.15%]相同，优于3FRCT[0.944(0.777~0.996)，92.3%]。7/3FRCT的预测阈值(0.791)比3FRCT(0.816)和2.7FRCT(0.787)更接近0.8.结论血流-直径标度律通过影响计算的出口边界条件Rm来影响FFRCT模拟。对于$Q\Alpha D{}^{7}\！\DIAGUP，FFRCT的诊断性能最高。血流-直径标度律为分叉血管内的血流分布提供了理论支持，并对FFRCT模型进行了改进。
OBJECTIVE To explore the influence of the blood flow-diameter scaling laws of $ \mathrm{Q}\mathrm{\alpha }{\mathrm{D}}^{3} $, $ \mathrm{Q}\mathrm{\alpha }{\mathrm{D}}^{2.7} $ and $ \text{Q}\alpha \text{D}{}^{7}\!\!\diagup\!\!{}_{3}\; $ on the numerical simulation of fraction flow reserve based on CTA images and to find the optimal exponents. METHODS 1) 26 patients with coronary artery disease were screened according to the inclusion criteria; 2) Microcirculation resistance (Rm) was calculated under the 3, 2.7 and 7/3 power of the flow-diameter scaling law, which were recorded as 3Rm, 2.7Rm and 7/3Rm, respectively; 3) 3Rm, 2.7Rm and 7/3Rm were used as exit boundary conditions to simulate FFRCT, quoted as 3FFRCT, 2.7FFRCT and 7/3FFRCT, respectively; 4) The correlation and diagnostic performance between three kinds of FFRCT and FFR were analyzed. RESULTS The p-values of comparing 3Rm, 2.7Rm and 7/3Rm with FFR were 0.004, 0.005 and 0.010, respectively; the r value between 7/3FFRCT and FFR (0.96) was better than that of 3FFRCT (0.95) and 2.7FFRCT (0.95); the 95% LoA between 7/3FFRCT and FFR (-0.08~0.11) was smaller than that of 3FFRCT (-0.10~0.12) and 2.7FFRCT (-0.09~0.11); the AUC and accuracy of 7/3FFRCT [0.962 (0.805-0.999), 96.15%] were the same as those of 2.7FFRCT [0.962 (0.805-0.999), 96.15%] and better than those of 3FFRCT [0.944 (0.777-0.996), 92.3%]. The prediction threshold of 7/3FFRCT (0.791) was closer to 0.8 than that of 3FFRCT (0.816) and 2.7FFRCT (0.787). CONCLUSION The blood flow-diameter scaling law affects the FFRCT simulation by influencing the exit boundary condition Rm of the calculation. With $ Q\alpha D{}^{7}\!\!\diagup\!\!{}_{3}\; $, FFRCT had the highest diagnostic performance. The blood flow-diameter scaling law provides theoretical support for the blood flow distribution in the bifurcated vessel and improves the FFRCT model.