Dietary Fat Increases Vitamin D-3 Absorption
Dietary Fat Increases Vitamin D-3 Absorption
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DOI：
10.1016/j.jand.2014.09.014
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发表时间：
2015-02-01
影响因子：
4.8
通讯作者：
Rasmussen, Helen
中科院分区：
文献类型：
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作者：
Dawson-Hughes, Bess;Harris, Susan S.;Rasmussen, Helen
背景血浆25-羟基维生素D对补充维生素D的反应变化很大，但维生素D的吸收差异的基础上的饮食组成知之甚少。目的我们测试的假设，即吸收的维生素D-3是更大时，补充剂是采取含脂肪的膳食比与无脂肪膳食，吸收更大时，膳食中的脂肪具有较高的单不饱和对-多不饱和脂肪酸比（MUFA：PUFA）.设计开放，三组，单剂量维生素D-3比较吸收实验.参与者/设置我们的为期1天的研究在50名健康的老年男性和女性中进行，他们被随机分配到三个膳食组之一：无脂肪膳食，以及具有低（1：4）和高（4：1）MUFA：PUFA的30%卡路里作为脂肪的膳食。在禁食12小时后，所有受试者在他们的测试早餐中服用50，000 IU维生素D-3补充剂。主要结果测量在给药前和给药后10，12（预期峰值）和14小时通过液相色谱质谱法测量血浆维生素D-3。进行统计分析。通过方差分析与重复测量subcommand的一般线性models procedure.Results剂量后的平均峰值（12小时）血浆维生素D-3水平的测量时间点的维生素D-3吸收组的差异是32%（95%CI 11%至52%）更大的受试者消耗含脂肪的脂肪相比，无脂肪餐（P = 0.003）。吸收没有显着差异，在任何时间点在高和低MUFA和PUFA groups.Conclusions的存在下，脂肪的膳食与维生素D-3补充剂采取显着提高吸收的补充剂，但MUFA：PUFA的脂肪在那顿饭不影响其吸收。
Background The plasma 25-hydroxyvitamin D response to supplementation with vitamin D varies widely, but vitamin D absorption differences based on diet composition is poorly understood.Objectives We tested the hypotheses that absorption of vitamin D-3 is greater when the supplement is taken with a meal containing fat than with a fat-free meal and that absorption is greater when the fat in the meal has a higher monounsaturated-to-polyunsaturated fatty acid ratio (MUFA:PUFA).Design Open, three-group, single-dose vitamin D-3 comparative absorption experiment.Participants/setting Our 1-day study was conducted in 50 healthy older men and women who were randomly assigned to one of three meal groups: fat-free meal, and a meal with 30% of calories as fat with a low (1:4) and one with a high (4:1) MUFA: PUFA. After a 12-hour fast, all subjects took a single 50,000 IU vitamin D-3 supplement with their test breakfast meal.Main outcome measures Plasma vitamin D-3 was measured by liquid chromatography emass spectrometry before and 10, 12 (the expected peak), and 14 hours after the dose.Statistical analyses performed Means were compared with two-tailed t tests for independent samples. Group differences in vitamin D-3 absorption across the measurement time points were examined by analysis of variance with the repeated measures subcommand of the general linear models procedure.Results The mean peak (12-hour) plasma vitamin D-3 level after the dose was 32% (95% CI 11% to 52%) greater in subjects consuming fat-containing compared with fat-free meals (P = 0.003). Absorption did not differ significantly at any time point in the high and low MUFA and PUFA groups.Conclusions The presence of fat in a meal with which a vitamin D-3 supplement is taken significantly enhances absorption of the supplement, but the MUFA: PUFA of the fat in that meal does not influence its absorption.