Comparison of Efficacy of Bromfenac Sodium 0.1% Ophthalmic Solution and Fluorometholone 0.02% Ophthalmic Suspension for the Treatment of Allergic Conjunctivitis
Comparison of Efficacy of Bromfenac Sodium 0.1% Ophthalmic Solution and Fluorometholone 0.02% Ophthalmic Suspension for the Treatment of Allergic Conjunctivitis
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DOI：
10.1089/jop.2008.0121
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发表时间：
2009-06-01
影响因子：
2.3
通讯作者：
Nakagawa, Yayoi
中科院分区：
文献类型：
--
作者：
Fujishima, Hiroshi;Fukagawa, Kazumi;Nakagawa, Yayoi
目的：比较0.1%溴芬酸钠（BF）与0.02%氟米龙（FML）联合2.0%色甘酸钠（DSCG）治疗季节性变态反应性结膜炎的疗效。对86例季节性过敏性结膜炎患者进行DSCG治疗，每日4次，在一只眼睛中每天两次同时施用BF，在对侧眼睛中每天四次施用FML，持续1周。眼部体征按4级严重程度评分。患者使用视觉模拟量表记录症状。结果：两组患者的主观症状评分均较治疗前下降（P <0.05），但两组患者的主观症状评分均较治疗前下降（P < 0.05）。BF或FML与DSCG联合应用可明显改善客观体征（P < 0.05）。BF和FML合并使用之间的症状和体征均无显著差异。15例患者选择BF，29例患者选择FML作为更首选的伴随滴眼液，42例患者判定两组间疗效无差异。结论：溴芬酸钠治疗过敏性结膜炎有效，与DSCG联合使用时疗效与FML相当。
Aims: Bromfenac sodium (BF) 0.1% was compared with fluorometholone (FML) 0.02% for the treatment of seasonal allergic conjunctivitis when concomitantly used with disodium cromoglycate (DSCG) 2.0%.Methods: Eighty-six patients with seasonal allergic conjunctivitis were treated with DSCG four times a day, and BF was concomitantly administered twice a day in one eye and FML was administered four times a day in the contralateral eye for 1 week. Ocular signs were scored on a four-graded severity. Patients recorded symptoms using visual analog scale. Patients were asked which concomitant treatment was more suitable for them and scored global evaluation.Results: All subjective symptom scores were decreased in both concomitant treatment groups compared with baseline (P < 0.05). Objective signs were significantly improved with the concomitant use of BF or FML with DSCG (P < 0.05). Neither symptoms nor signs differed significantly between the concomitant use of BF and FML. Fifteen patients selected BF and 29 patients selected FML as the more preferred concomitant eye drops, 42 patients judged no difference in efficacy between the groups. No significant difference was observed in patient's global evaluation between the groups.Conclusions: Bromfenac sodium for allergic conjunctivitis was effective, with efficacy equivalent to that of FML when used with DSCG.