Association of Diabetes and Glycated Hemoglobin With the Risk of Intracerebral Hemorrhage: A Population-Based Cohort Study
Association of Diabetes and Glycated Hemoglobin With the Risk of Intracerebral Hemorrhage: A Population-Based Cohort Study
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DOI：
10.2337/dc18-2472
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发表时间：
2019-04-01
期刊：
影响因子：
16.2
通讯作者：
Auriel, Eitan
中科院分区：
文献类型：
--
作者：
Saliba, Walid;Barnett-Griness, Ofra;Auriel, Eitan
目的：在一个大的人群队列中，研究糖尿病和糖化血红蛋白（HbA（1c））与脑出血（ICH）风险之间的关系。研究设计和方法：以色列最大的医疗保健提供者的计算机化数据库用于识别年龄在40岁或40岁以上且在2010年1月1日存活的成年成员（297，486例糖尿病患者和1，167，585例非糖尿病患者）。对该队列的ICH发生率进行随访，直至2017年12月31日。采用多变量考克斯比例风险回归模型，校正基线疾病风险评分，估计ICH的风险比（HR）。糖尿病与ICH风险增加独立相关，风险比（HR）为1.36（95% CI 1.27-1.45），并随糖尿病病程延长而增加：糖尿病病程5年的风险比分别为1.23（1.12-1.35）和1.44（1.34-1.56）。与糖尿病相关的ICH风险增加在患者中更为明显
OBJECTIVETo examine the association of diabetes and glycated hemoglobin (HbA(1c)) with the risk of intracerebral hemorrhage (ICH) in a large population-based cohort.RESEARCH DESIGN AND METHODSThe computerized database of the largest health care provider in Israel was used to identify adult members aged 40 years or older and alive at 1 January 2010 (297,486 with diabetes and 1,167,585 without diabetes). The cohort was followed until 31 December 2017 for incidence of ICH. Multivariable Cox proportional hazards regression models, adjusted for baseline disease risk score, were applied to estimate the hazard ratio (HR) of ICH.RESULTSOverall 4,170 ICH cases occurred during 10,730,915 person-years of follow-up. Diabetes was independently associated with increased ICH risk, with hazard ratio (HR) 1.36 (95% CI 1.27-1.45), and increased with longer diabetes duration: 1.23 (1.12-1.35) and 1.44 (1.34-1.56) for diabetes duration 5 years, respectively. The increased ICH risk associated with diabetes was more pronounced in patients