Evidence for Shear Stress-Mediated Dilation of the Internal Carotid Artery in Humans
Evidence for Shear Stress-Mediated Dilation of the Internal Carotid Artery in Humans
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DOI：
10.1161/hypertensionaha.116.07698
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发表时间：
2016-11-01
期刊：
影响因子：
8.3
通讯作者：
Green, Daniel J.
中科院分区：
文献类型：
--
作者：
Carter, Howard H.;Atkinson, Ceri L.;Green, Daniel J.
动脉二氧化碳浓度升高（高碳酸血症）引起脑小动脉的强效血管扩张。最近的研究也报道了高碳酸血症期间颈内动脉血管舒张，但介导这种颅外血管反应的机制尚不清楚。高碳酸血症增加颈动脉剪切应力，已知刺激其他导管动脉血管舒张。为了探索剪切应力导致人类高碳酸血症内颈动脉扩张的假设，我们同时评估了18名受试者在休息和高碳酸血症（6%二氧化碳）期间内颈动脉和总颈动脉剪切速率和直径的时间变化，以及大脑中动脉速度的变化。大脑中动脉流速明显增高(69 +/- 10 ~ 103 +/- 17 cm/s
Increases in arterial carbon dioxide tension (hypercapnia) elicit potent vasodilation of cerebral arterioles. Recent studies have also reported vasodilation of the internal carotid artery during hypercapnia, but the mechanism(s) mediating this extracranial vasoreactivity are unknown. Hypercapnia increases carotid shear stress, a known stimulus to vasodilation in other conduit arteries. To explore the hypothesis that shear stress contributes to hypercapnic internal carotid dilation in humans, temporal changes in internal and common carotid shear rate and diameter, along with changes in middle cerebral artery velocity, were simultaneously assessed in 18 subjects at rest and during hypercapnia (6% carbon dioxide). Middle cerebral artery velocity increased significantly (69 +/- 10-103 +/- 17 cm/s; P