Hepatitis B virus (HBV) hepatitis D virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian Amazon Basin: The roles of HDV genotype III and HBV genotype F
Hepatitis B virus (HBV) hepatitis D virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian Amazon Basin: The roles of HDV genotype III and HBV genotype F
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DOI：
10.1093/infdis/174.5.920
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发表时间：
1996-11-01
影响因子：
6.4
通讯作者：
Gerin, JL
中科院分区：
文献类型：
--
作者：
Casey, JL;Niro, GA;Gerin, JL
反复爆发的急性肝炎是驻扎在秘鲁亚马逊流域地区的秘鲁军事人员发病和死亡的一个重要原因。对 1992 年至 1993 年间驻扎在四个不同丛林前哨的 88 名军人患者中的乙型肝炎病毒 (HBV) 和丁型肝炎病毒 (HDV) 感染作为急性肝炎的可能原因进行了调查。血清标志物分析表明，95%（84/88）有急性乙型肝炎病毒感染的证据； 64% (54/84) 的人也感染了 HDV，PCR 扩增的 HDV 和 HBV 片段的遗传分析仅显示 HDV 基因型 III 和 HBV 基因型 F。此外，来自同一前哨站的患者之间的 HDV RNA 序列相似，但与其他丛林地点的患者不同。这些数据提示了前哨丛林环境中丁型肝炎病毒感染的焦点来源，并进一步证实了丁型肝炎病毒基因型 III 与南美洲北部严重人类疾病病例的独特关联。
Recurring outbreaks of acute hepatitis have been a significant cause of morbidity and mortality among Peruvian military personnel stationed in the Amazon Basin region of Peru. The role of hepatitis B virus (HBV) and hepatitis D virus (HDV) infection was investigated as the possible cause of acute hepatitis among 88 military patients stationed at four different jungle outposts during 1992-1993. Analysis of serum markers indicated that 95% (84/88) had evidence of acute HBV infection; 64% (54/84) mere also infected with HDV, Genetic analysis of PCR-amplified HDV and HBV fragments showed exclusively HDV genotype III and HBV genotype F. Furthermore, HDV RNA sequences were similar among patients from the same outpost but different from those at other jungle locations. The data suggested focal sources of HDV infection in the jungle environment of the outposts and, further, confirmed the unique association of HDV genotype III with severe cases of human disease in northern South America.