ABC transporter ABCA3 is expressed in acute myeloid leukemia blast cells and participates in vesicular transport.
ABC transporter ABCA3 is expressed in acute myeloid leukemia blast cells and participates in vesicular transport.
复制标题
DOI：
--
复制
发表时间：
2004
期刊：
影响因子：
10.1
通讯作者：
G. Wulf;S. Modlich;N. Inagaki;D. Reinhardt;R. Schroers;F. Griesinger;L. Trümper
中科院分区：
文献类型：
--
作者：
G. Wulf;S. Modlich;N. Inagaki;D. Reinhardt;R. Schroers;F. Griesinger;L. Trümper
耐药是急性髓系白血病（AML）治疗中的主要问题，ATP结合盒（ABC）转运体的药物外排是耐药的主要机制之一。我们确定了AML患者标本中细胞内转运蛋白ABCA 3的患病率，并关注其细胞内区室化的生物学。
Drug resistance is a major issue in the treatment of acute myeloid leukemia (AML), and drug efflux by ATP-binding-cassette (ABC) transporters is one of the main mechanism involved in this resistance. We determined the prevalence of the intracellular transporter ABCA3 in specimens from patients with AML, and addressed its biology with attention to intracellular compartmentalization.